{"id":1068,"date":"2026-06-10T02:28:09","date_gmt":"2026-06-09T18:28:09","guid":{"rendered":"https:\/\/www.protacs.com\/?p=1068"},"modified":"2026-06-10T12:26:53","modified_gmt":"2026-06-10T04:26:53","slug":"monte-rosa-therapeutics","status":"publish","type":"post","link":"https:\/\/www.protacs.com\/monte-rosa-therapeutics\/","title":{"rendered":"Monte Rosa Therapeutics\uff1a\u5206\u5b50\u80f6\u964d\u89e3\u5242\uff08Molecular Glue\uff09\u7406\u6027\u8bbe\u8ba1\u5148\u950b"},"content":{"rendered":"<p><strong>\u4e00\u53e5\u8bdd\u5b9a\u4f4d\uff1a<\/strong>\u4ee5&#8221;\u5206\u5b50\u80f6&#8221;\u4e3a\u65d7\u5e1c\u3001\u7528 QuEEN \u5e73\u53f0\u7406\u6027\u8bbe\u8ba1\u80f6\u6c34\u964d\u89e3\u5242\u7684\u4ee3\u8868\u3002<\/p>\n<table class=\"company-facts\" border=\"1\" cellpadding=\"6\" cellspacing=\"0\" style=\"border-collapse:collapse;width:100%\">\n<tr>\n<th style=\"text-align:left;width:120px;background:#f5f7fa\">\u82f1\u6587\u540d\u79f0<\/th>\n<td>Monte Rosa Therapeutics, Inc.<\/td>\n<\/tr>\n<tr>\n<th style=\"text-align:left;width:120px;background:#f5f7fa\">\u603b\u90e8<\/th>\n<td>\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u6ce2\u58eb\u987f<\/td>\n<\/tr>\n<tr>\n<th style=\"text-align:left;width:120px;background:#f5f7fa\">\u6210\u7acb\u65f6\u95f4<\/th>\n<td>2018 \u5e74<\/td>\n<\/tr>\n<tr>\n<th style=\"text-align:left;width:120px;background:#f5f7fa\">\u4e0a\u5e02\/\u878d\u8d44<\/th>\n<td>\u7eb3\u65af\u8fbe\u514b\u4e0a\u5e02\uff0c\u4ee3\u7801 GLUE<\/td>\n<\/tr>\n<tr>\n<th style=\"text-align:left;width:120px;background:#f5f7fa\">\u6280\u672f\u6a21\u6001<\/th>\n<td>\u5206\u5b50\u80f6\u964d\u89e3\u5242\uff08Molecular Glue Degrader\uff09<\/td>\n<\/tr>\n<\/table>\n<h2>\u516c\u53f8\u6982\u51b5<\/h2>\n<p>Monte Rosa \u4e13\u6ce8\u5206\u5b50\u80f6\u964d\u89e3\u5242\u2014\u2014\u7528\u5c0f\u5206\u5b50\u8bf1\u5bfc\u9776\u86cb\u767d\u4e0e E3 \u8fde\u63a5\u9176\u4e4b\u95f4\u7684&#8221;\u65b0\u751f\u754c\u9762&#8221;\uff0c\u4ece\u800c\u964d\u89e3\u4f20\u7edf\u96be\u6210\u836f\u9776\u70b9\uff0c\u80a1\u7968\u4ee3\u7801\u76f4\u63a5\u7528\u4e86 GLUE\u3002<\/p>\n<h2>\u6280\u672f\u5e73\u53f0<\/h2>\n<p><strong>QuEEN<\/strong>\uff08Quantitative and Engineered Elimination of Neosubstrates\uff09\u5e73\u53f0\u6574\u5408\u86cb\u767d\u7ec4\u5b66\u3001\u7ed3\u6784\u751f\u7269\u5b66\u4e0e\u673a\u5668\u5b66\u4e60\uff0c\u7cfb\u7edf\u5316\u7b5b\u9009\u4e0e\u8bbe\u8ba1\u5206\u5b50\u80f6\u3002<\/p>\n<h2>\u6838\u5fc3\u7ba1\u7ebf<\/h2>\n<ul>\n<li><strong>MRT-2359<\/strong>\uff1aGSPT1 \u5206\u5b50\u80f6\u964d\u89e3\u5242\uff0c\u7528\u4e8e MYC \u9a71\u52a8\u7684\u80ba\u764c\u7b49\u5b9e\u4f53\u7624\u3002<\/li>\n<li><strong>MRT-6160<\/strong>\uff1aVAV1 \u964d\u89e3\u5242\uff0c\u4e0e\u8bfa\u534e\u5408\u4f5c\uff0c\u9762\u5411\u514d\u75ab\u708e\u75c7\u9002\u5e94\u75c7\u3002<\/li>\n<li>CDK2\u3001NEK7 \u7b49\u591a\u4e2a\u5206\u5b50\u80f6\u9879\u76ee\u3002<\/li>\n<\/ul>\n<h2>\u5408\u4f5c\u4e0e\u8d44\u672c<\/h2>\n<p>\u4e0e\u8bfa\u534e\uff08VAV1\uff09\u3001\u7f57\u6c0f\u7b49\u8fbe\u6210\u5408\u4f5c\uff0c\u514d\u75ab\u65b9\u5411\u83b7\u5f97\u9a8c\u8bc1\u3002<\/p>\n<h2>\u770b\u70b9\u7b80\u8bc4<\/h2>\n<p>\u5206\u5b50\u80f6\u76f8\u6bd4 PROTAC \u5206\u5b50\u91cf\u66f4\u5c0f\u3001\u66f4\u6613\u53e3\u670d\uff0cMonte Rosa \u62bc\u6ce8\u7684\u662f&#8221;\u53ef\u7406\u6027\u8bbe\u8ba1\u5206\u5b50\u80f6&#8221;\u8fd9\u4e00\u957f\u671f\u5e73\u53f0\u4ef7\u503c\u3002<\/p>\n<p style=\"color:#888;font-size:13px\">\u6ce8\uff1a\u672c\u6863\u6848\u57fa\u4e8e\u516c\u5f00\u4fe1\u606f\u6574\u7406\uff0c\u7ba1\u7ebf\u4e0e\u5408\u4f5c\u72b6\u6001\u53ef\u80fd\u968f\u65f6\u95f4\u53d8\u5316\uff0c\u4ee5\u516c\u53f8\u5b98\u65b9\u62ab\u9732\u4e3a\u51c6\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4ee5&#8221;\u5206\u5b50\u80f6&#8221;\u4e3a\u65d7\u5e1c\u3001\u7528 QuEEN \u5e73\u53f0\u7406\u6027\u8bbe\u8ba1\u80f6\u6c34\u964d\u89e3\u5242\u7684\u4ee3\u8868\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[45,71,73,72,59,74],"class_list":["post-1068","post","type-post","status-publish","format-standard","hentry","category-company","tag-gspt1","tag-monte-rosa","tag-queen","tag-vav1","tag-59","tag-74"],"_links":{"self":[{"href":"https:\/\/www.protacs.com\/wp-json\/wp\/v2\/posts\/1068","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.protacs.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.protacs.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.protacs.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.protacs.com\/wp-json\/wp\/v2\/comments?post=1068"}],"version-history":[{"count":1,"href":"https:\/\/www.protacs.com\/wp-json\/wp\/v2\/posts\/1068\/revisions"}],"predecessor-version":[{"id":1122,"href":"https:\/\/www.protacs.com\/wp-json\/wp\/v2\/posts\/1068\/revisions\/1122"}],"wp:attachment":[{"href":"https:\/\/www.protacs.com\/wp-json\/wp\/v2\/media?parent=1068"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.protacs.com\/wp-json\/wp\/v2\/categories?post=1068"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.protacs.com\/wp-json\/wp\/v2\/tags?post=1068"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}