/*
Theme Name: PROTACS Molecular Editorial
Theme URI: https://www.protacs.com/
Author: PROTACS Editorial
Author URI: https://www.protacs.com/
Description: 为 PROTAC 与靶向蛋白降解领域的中文情报站设计的编辑型主题。深色生物科技配色、期刊式排版、本地系统字体栈，配合精心设计的首页 / 文章 / 归档 / 靶点档案四类模板。Dark biotech color palette, journal-grade typography, and self-host friendly system font stacks.
Version: 1.1.1
Requires at least: 6.0
Tested up to: 6.5
Requires PHP: 7.4
License: GNU General Public License v2 or later
License URI: http://www.gnu.org/licenses/gpl-2.0.html
Text Domain: protacs-molecular-editorial
Tags: dark, custom-colors, custom-menu, featured-images, sticky-post, threaded-comments, translation-ready, editorial, blog, biotech
*/

/* ==========================================================================
   Note: All design CSS lives in this file (loaded by WP via wp_head()).
   Theme tokens are defined in :root below — override there to re-skin.
   ========================================================================== */

/* =========================================================
   PROTACS — Molecular Editorial Theme
   ========================================================= */
:root {
  --bg:           #08101C;
  --bg-2:         #0B1424;
  --surface:      #11192C;
  --surface-2:    #182241;
  --border:       #1B2742;
  --border-2:     #243355;
  --text:         #ECEFF6;
  --text-2:       #B6BED1;
  --text-3:       #7C8499;
  --text-4:       #545C72;
  --cyan:         #6EE7E7;
  --cyan-deep:    #34B7CE;
  --lime:         #B8E869;
  --amber:        #F0B061;
  --rose:         #F58A8A;
  --signal:       #6EE7E7;
  --serif-zh:     'Songti SC', 'STSong', SimSun, 'Noto Serif CJK SC', serif;
  --sans-zh:      -apple-system, BlinkMacSystemFont, 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei', 'Noto Sans CJK SC', sans-serif;
  --kai:          'Kaiti SC', KaiTi, STKaiti, var(--serif-zh);
  --serif:        'Iowan Old Style', 'New York', Georgia, var(--serif-zh);
  --sans:         var(--sans-zh);
  --mono:         'SFMono-Regular', 'Menlo', 'Monaco', 'Consolas', var(--sans-zh), ui-monospace, monospace;
  --max:          1320px;
  --pad:          clamp(20px, 4vw, 56px);
}

* { box-sizing: border-box; margin: 0; padding: 0; }
html { scroll-behavior: smooth; }
body {
  font-family: var(--sans);
  font-weight: 400;
  background: var(--bg);
  color: var(--text);
  line-height: 1.7;
  font-feature-settings: "ss01", "ss02", "cv11", "palt" 1;
  font-variant-east-asian: proportional-width;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  text-rendering: optimizeLegibility;
  overflow-x: hidden;
  hanging-punctuation: allow-end last;
  text-spacing-trim: trim-start;
}

/* CJK-aware refinements: Chinese characters need slight positive tracking
   and proportional alternates ("palt") to avoid the slabby full-width gap. */
:lang(zh-CN), :lang(zh) {
  font-feature-settings: "palt" 1, "kern" 1;
  letter-spacing: 0.01em;
}

/* Latin letters and numerals embedded inside Chinese text need a hair of
   side-bearing — this is the well-known 中英混排 problem. */
.cn em, .cn strong, .cn-spacer { margin: 0 0.12em; }

::selection { background: var(--cyan); color: var(--bg); }

/* Background atmosphere */
body::before {
  content: '';
  position: fixed; inset: 0;
  background:
    radial-gradient(ellipse 60% 50% at 15% 0%, rgba(110, 231, 231, 0.07), transparent 60%),
    radial-gradient(ellipse 50% 40% at 85% 20%, rgba(184, 232, 105, 0.04), transparent 60%),
    radial-gradient(ellipse 80% 60% at 50% 110%, rgba(110, 231, 231, 0.05), transparent 60%);
  pointer-events: none;
  z-index: 0;
}
body::after {
  content: '';
  position: fixed; inset: 0;
  background-image: url("data:image/svg+xml,%3Csvg viewBox='0 0 200 200' xmlns='http://www.w3.org/2000/svg'%3E%3Cfilter id='n'%3E%3CfeTurbulence type='fractalNoise' baseFrequency='0.9' numOctaves='3'/%3E%3C/filter%3E%3Crect width='100%25' height='100%25' filter='url(%23n)' opacity='0.5'/%3E%3C/svg%3E");
  opacity: 0.025;
  mix-blend-mode: overlay;
  pointer-events: none;
  z-index: 1;
}

/* ===== Layout primitives ===== */
.wrap { max-width: var(--max); margin: 0 auto; padding-inline: var(--pad); position: relative; z-index: 2; }
section { position: relative; z-index: 2; }

a { color: inherit; text-decoration: none; }

/* Universal eyebrow / section labels (mono technical) */
.eyebrow {
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  color: var(--cyan);
  display: inline-flex;
  align-items: center;
  gap: 10px;
}
.eyebrow::before {
  content: '';
  width: 24px; height: 1px;
  background: linear-gradient(90deg, transparent, var(--cyan));
}

/* ===== Topbar ===== */
.topbar {
  position: sticky; top: 0; z-index: 50;
  backdrop-filter: blur(18px) saturate(140%);
  -webkit-backdrop-filter: blur(18px) saturate(140%);
  background: rgba(8, 16, 28, 0.72);
  border-bottom: 1px solid var(--border);
}
.topbar-inner {
  max-width: var(--max);
  margin: 0 auto;
  padding: 14px var(--pad);
  display: flex;
  align-items: center;
  gap: 32px;
}
/* Anchor refinement: when a brand wordmark is paired with Chinese tag, mix nicely */
.brand {
  display: flex; align-items: center; gap: 12px;
  font-family: var(--serif);
  font-weight: 600;
  font-size: 19px;
  letter-spacing: 0.005em;
}
.brand-mark {
  width: 28px; height: 28px;
  position: relative;
  display: grid; place-items: center;
}
.brand-mark svg { width: 100%; height: 100%; }
.brand-tag {
  font-family: var(--kai);
  font-size: 13px;
  letter-spacing: 0.08em;
  color: var(--cyan);
  border: 1px solid rgba(110, 231, 231, 0.25);
  padding: 2px 9px;
  border-radius: 3px;
  margin-left: 4px;
  font-weight: 400;
  background: rgba(110, 231, 231, 0.04);
}
.nav { display: flex; gap: 30px; margin-left: auto; }
.nav a {
  font-size: 14.5px;
  color: var(--text-2);
  position: relative;
  padding: 6px 0;
  transition: color 0.2s;
  letter-spacing: 0.02em;
}
.nav a:hover { color: var(--text); }
.nav a::after {
  content: '';
  position: absolute; left: 0; bottom: 0;
  width: 0; height: 1px;
  background: var(--cyan);
  transition: width 0.25s;
}
.nav a:hover::after { width: 100%; }

.topbar-tools { display: flex; align-items: center; gap: 10px; }
.search-trigger {
  display: flex; align-items: center; gap: 8px;
  padding: 6px 10px 6px 12px;
  border: 1px solid var(--border-2);
  border-radius: 999px;
  font-size: 13px;
  font-family: var(--sans);
  color: var(--text-3);
  background: transparent;
  cursor: pointer;
  transition: all 0.2s;
}
.search-trigger svg { width: 13px; height: 13px; }
.search-trigger kbd {
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.04em;
  color: var(--text-4);
  border: 1px solid var(--border-2);
  border-radius: 3px;
  padding: 1px 5px;
  background: var(--bg);
}
.search-trigger:hover { border-color: var(--cyan); color: var(--cyan); }
.search-trigger:hover kbd { color: var(--cyan); border-color: rgba(110, 231, 231, 0.3); }

.topbar-cta {
  display: flex; align-items: center; gap: 8px;
  padding: 7px 14px;
  border: 1px solid var(--border-2);
  border-radius: 999px;
  font-size: 12px;
  font-family: var(--mono);
  color: var(--text-2);
  transition: all 0.2s;
}
.topbar-cta:hover { border-color: var(--cyan); color: var(--cyan); }
.topbar-cta .dot {
  width: 6px; height: 6px;
  background: var(--lime);
  border-radius: 50%;
  box-shadow: 0 0 8px var(--lime);
  animation: pulse 2s infinite;
}
@keyframes pulse {
  0%, 100% { opacity: 1; }
  50% { opacity: 0.4; }
}

/* ===== HERO ===== */
.hero {
  padding: clamp(60px, 9vw, 120px) 0 clamp(40px, 6vw, 80px);
  position: relative;
  overflow: hidden;
}
.hero-grid {
  display: grid;
  grid-template-columns: 1.15fr 1fr;
  gap: clamp(30px, 5vw, 80px);
  align-items: center;
}
.hero-meta {
  display: flex;
  align-items: center;
  gap: 16px;
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.12em;
  color: var(--text-3);
  text-transform: uppercase;
  margin-bottom: 32px;
}
.hero-meta .sep { color: var(--text-4); }
.hero-meta .live {
  display: inline-flex; align-items: center; gap: 6px;
  color: var(--lime);
}
.hero-meta .live::before {
  content: '';
  width: 6px; height: 6px;
  border-radius: 50%;
  background: var(--lime);
  box-shadow: 0 0 10px var(--lime);
  animation: pulse 1.6s infinite;
}

h1.hero-title {
  font-family: var(--serif);
  font-weight: 400;
  font-size: clamp(40px, 6vw, 80px);
  line-height: 1.08;
  letter-spacing: -0.025em;
  margin-bottom: 28px;
  font-variation-settings: "opsz" 144, "SOFT" 30, "WONK" 0;
  color: var(--text);
  hanging-punctuation: allow-end;
}
/* Chinese accent words render in LXGW WenKai (a warm kai-script face) —
   this gives Chinese the editorial-italic feeling that real italic can't. */
h1.hero-title em.cn {
  font-family: var(--kai);
  font-style: normal;
  font-weight: 400;
  font-variation-settings: normal;
  letter-spacing: 0.04em;
  background: linear-gradient(120deg, var(--cyan), var(--lime));
  -webkit-background-clip: text;
  background-clip: text;
  -webkit-text-fill-color: transparent;
  padding: 0 0.04em;
}
/* Latin accent words keep the gorgeous Fraunces italic. */
h1.hero-title em:not(.cn) {
  font-style: italic;
  font-weight: 300;
  font-variation-settings: "opsz" 144, "SOFT" 100, "WONK" 1;
  color: var(--cyan);
  background: linear-gradient(120deg, var(--cyan), var(--lime));
  -webkit-background-clip: text;
  background-clip: text;
  -webkit-text-fill-color: transparent;
}
h1.hero-title .small {
  font-family: var(--sans);
  font-size: 0.32em;
  display: block;
  color: var(--text-3);
  font-style: normal;
  margin-top: 22px;
  letter-spacing: 0;
  line-height: 1.7;
  font-weight: 300;
}

.hero-sub {
  font-size: 17px;
  line-height: 1.85;
  color: var(--text-2);
  max-width: 540px;
  margin-bottom: 36px;
  letter-spacing: 0.01em;
}

.hero-actions { display: flex; gap: 14px; flex-wrap: wrap; }
.btn {
  display: inline-flex;
  align-items: center;
  gap: 10px;
  padding: 14px 22px;
  font-size: 14px;
  font-weight: 500;
  border-radius: 4px;
  transition: all 0.25s;
  border: 1px solid transparent;
  font-family: var(--sans);
}
.btn-primary {
  background: var(--cyan);
  color: var(--bg);
  font-weight: 600;
}
.btn-primary:hover {
  background: var(--lime);
  transform: translateY(-1px);
  box-shadow: 0 12px 30px -10px rgba(184, 232, 105, 0.4);
}
.btn-ghost {
  background: transparent;
  color: var(--text);
  border-color: var(--border-2);
}
.btn-ghost:hover {
  border-color: var(--cyan);
  color: var(--cyan);
}
.btn .arrow { transition: transform 0.25s; }
.btn:hover .arrow { transform: translateX(4px); }

/* Hero molecule visual */
.hero-visual {
  position: relative;
  aspect-ratio: 1 / 1;
  max-width: 560px;
  margin-left: auto;
}
.hero-visual svg { width: 100%; height: 100%; }

/* Stats ribbon under hero */
.stats {
  margin-top: clamp(50px, 7vw, 90px);
  border-top: 1px solid var(--border);
  border-bottom: 1px solid var(--border);
  display: grid;
  grid-template-columns: repeat(4, 1fr);
}
.stat {
  padding: 28px 28px 26px;
  border-right: 1px solid var(--border);
  position: relative;
}
.stat:last-child { border-right: none; }
.stat-label {
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.18em;
  color: var(--text-3);
  text-transform: uppercase;
  margin-bottom: 14px;
  display: flex;
  align-items: center;
  gap: 8px;
}
.stat-label::before {
  content: '';
  width: 4px; height: 4px;
  background: var(--cyan);
  border-radius: 50%;
}
.stat-num {
  font-family: var(--serif);
  font-size: clamp(36px, 4vw, 52px);
  font-weight: 300;
  font-variation-settings: "opsz" 144, "SOFT" 100;
  line-height: 1;
  color: var(--text);
  font-feature-settings: "tnum";
}
.stat-num em {
  font-style: italic;
  font-weight: 300;
  color: var(--cyan);
}
.stat-desc {
  font-size: 13px;
  color: var(--text-3);
  margin-top: 8px;
}

/* ===== Featured Lead Story ===== */
.featured {
  padding: clamp(60px, 9vw, 110px) 0 clamp(40px, 6vw, 70px);
}
.section-head {
  display: flex;
  align-items: end;
  justify-content: space-between;
  gap: 24px;
  margin-bottom: 40px;
  padding-bottom: 24px;
  border-bottom: 1px solid var(--border);
}
.section-head h2 {
  font-family: var(--serif);
  font-weight: 400;
  font-size: clamp(28px, 3.5vw, 44px);
  line-height: 1.15;
  letter-spacing: -0.018em;
  font-variation-settings: "opsz" 80, "SOFT" 50;
}
.section-head h2 em:not(.cn) {
  font-style: italic;
  font-weight: 300;
  color: var(--cyan);
}
.section-head h2 em.cn {
  font-family: var(--kai);
  font-style: normal;
  font-weight: 400;
  letter-spacing: 0.05em;
  color: var(--cyan);
  padding: 0 0.06em;
}
.section-head .meta-right {
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--text-3);
  white-space: nowrap;
  display: flex;
  align-items: center;
  gap: 10px;
}
.section-head .meta-right .link-arrow {
  color: var(--cyan);
  transition: gap 0.25s;
  display: inline-flex;
  align-items: center;
  gap: 6px;
}
.section-head .meta-right .link-arrow:hover { gap: 10px; }

.lead-card {
  display: grid;
  grid-template-columns: 1.05fr 1fr;
  gap: 0;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 6px;
  overflow: hidden;
  transition: border-color 0.3s;
  position: relative;
}
.lead-card:hover { border-color: var(--cyan-deep); }
.lead-card .lead-image {
  position: relative;
  background: linear-gradient(135deg, #102035, #1A2A4A);
  aspect-ratio: 4 / 3;
  overflow: hidden;
}
.lead-card .lead-image::after {
  content: '';
  position: absolute; inset: 0;
  background: linear-gradient(220deg, transparent 50%, rgba(110, 231, 231, 0.08));
}
.lead-image-art {
  position: absolute;
  inset: 0;
  display: grid;
  place-items: center;
  opacity: 0.9;
}
.lead-image-art svg { width: 88%; height: 88%; }

.lead-meta-strip {
  position: absolute;
  top: 18px; left: 18px; right: 18px;
  display: flex;
  justify-content: space-between;
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--text-2);
}
.lead-meta-strip .tag {
  background: rgba(8, 16, 28, 0.7);
  padding: 5px 10px;
  border: 1px solid var(--border-2);
  border-radius: 3px;
  color: var(--cyan);
  backdrop-filter: blur(6px);
}

.lead-body {
  padding: clamp(28px, 3.5vw, 52px);
  display: flex;
  flex-direction: column;
  justify-content: space-between;
}
.lead-body .crumb {
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.14em;
  text-transform: uppercase;
  color: var(--text-3);
  margin-bottom: 24px;
  display: flex;
  gap: 12px;
  align-items: center;
}
.lead-body .crumb .pill {
  display: inline-block;
  padding: 4px 10px;
  background: rgba(110, 231, 231, 0.08);
  border: 1px solid rgba(110, 231, 231, 0.25);
  border-radius: 999px;
  color: var(--cyan);
}
.lead-body h3 {
  font-family: var(--serif);
  font-weight: 500;
  font-size: clamp(24px, 2.6vw, 34px);
  line-height: 1.35;
  letter-spacing: -0.005em;
  margin-bottom: 18px;
  font-variation-settings: "opsz" 60, "SOFT" 40;
}
.lead-body h3 a:hover { color: var(--cyan); }
.lead-body p {
  font-size: 15px;
  line-height: 1.85;
  color: var(--text-2);
  margin-bottom: 28px;
  letter-spacing: 0.005em;
}
.lead-body .lead-foot {
  display: flex;
  justify-content: space-between;
  align-items: center;
  padding-top: 22px;
  border-top: 1px solid var(--border);
}
.byline {
  font-family: var(--mono);
  font-size: 12px;
  letter-spacing: 0.06em;
  color: var(--text-3);
}
.byline em { color: var(--text); font-style: normal; }
.read-more {
  font-family: var(--sans);
  font-size: 13px;
  letter-spacing: 0.04em;
  color: var(--cyan);
  display: inline-flex;
  align-items: center;
  gap: 10px;
  transition: gap 0.25s;
  font-weight: 500;
}
.read-more:hover { gap: 14px; }

/* ===== Three Pillars ===== */
.pillars {
  padding: clamp(40px, 6vw, 70px) 0;
}
.pillars-grid {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 1px;
  background: var(--border);
  border: 1px solid var(--border);
  border-radius: 6px;
  overflow: hidden;
}
.pillar {
  background: var(--surface);
  padding: 36px 32px 32px;
  display: flex;
  flex-direction: column;
  gap: 20px;
  transition: background 0.3s;
  position: relative;
}
.pillar:hover { background: var(--surface-2); }
.pillar-head {
  display: flex;
  align-items: start;
  justify-content: space-between;
  gap: 16px;
  padding-bottom: 18px;
  border-bottom: 1px dashed var(--border-2);
}
.pillar-head .pillar-icon {
  width: 42px; height: 42px;
  display: grid; place-items: center;
  border: 1px solid var(--border-2);
  border-radius: 4px;
  background: rgba(110, 231, 231, 0.04);
}
.pillar-head .pillar-icon svg { width: 22px; height: 22px; stroke: var(--cyan); }
.pillar-head .pillar-count {
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.1em;
  color: var(--text-3);
  text-align: right;
}
.pillar-head .pillar-count em {
  font-style: normal;
  font-size: 28px;
  font-family: var(--serif);
  color: var(--text);
  font-weight: 300;
  display: block;
  line-height: 1;
  margin-bottom: 4px;
}
.pillar h3 {
  font-family: var(--serif);
  font-weight: 500;
  font-size: 26px;
  letter-spacing: 0;
  font-variation-settings: "opsz" 60;
  line-height: 1.3;
}
.pillar h3 .lat {
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  color: var(--cyan);
  display: block;
  margin-bottom: 12px;
  font-weight: 400;
}
.pillar p.pillar-desc {
  font-size: 14px;
  color: var(--text-2);
  line-height: 1.85;
  letter-spacing: 0.01em;
}
.pillar-list {
  list-style: none;
  margin-top: 8px;
  display: flex;
  flex-direction: column;
  gap: 12px;
}
.pillar-list li {
  display: grid;
  grid-template-columns: 70px 1fr;
  gap: 14px;
  align-items: baseline;
  padding: 8px 0;
  border-bottom: 1px solid var(--border);
  transition: border-color 0.2s;
}
.pillar-list li:hover { border-bottom-color: var(--cyan-deep); }
.pillar-list li:last-child { border-bottom: none; }
.pillar-list .date {
  font-family: var(--mono);
  font-size: 11px;
  color: var(--text-3);
  letter-spacing: 0.05em;
}
.pillar-list .title {
  font-size: 13.5px;
  color: var(--text);
  line-height: 1.65;
  transition: color 0.2s;
  letter-spacing: 0.01em;
}
.pillar-list a:hover .title { color: var(--cyan); }
.pillar-cta {
  margin-top: auto;
  padding-top: 18px;
  font-family: var(--sans);
  font-size: 13px;
  letter-spacing: 0.06em;
  color: var(--cyan);
  display: inline-flex;
  align-items: center;
  gap: 10px;
  transition: gap 0.25s;
  align-self: flex-start;
  font-weight: 500;
}
.pillar-cta::before {
  content: '';
  width: 18px; height: 1px;
  background: var(--cyan);
  transition: width 0.25s;
}
.pillar-cta:hover::before { width: 26px; }
.pillar-cta:hover { gap: 14px; }

/* ===== Latest / Fresh Reading timeline ===== */
.latest {
  padding: clamp(60px, 9vw, 100px) 0;
}
.latest-grid {
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 24px;
}
.entry {
  display: grid;
  grid-template-columns: 88px 1fr 140px;
  gap: 28px;
  padding: 26px 0;
  border-top: 1px solid var(--border);
  align-items: start;
  transition: padding 0.3s;
  position: relative;
}
.entry::before {
  content: '';
  position: absolute;
  top: -1px; left: 0;
  width: 0; height: 1px;
  background: var(--cyan);
  transition: width 0.4s;
}
.entry:hover::before { width: 100%; }
.entry:hover { padding-left: 8px; }
.entry .e-date {
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.06em;
  color: var(--text-3);
  padding-top: 4px;
}
.entry .e-date strong {
  display: block;
  font-family: var(--serif);
  font-size: 28px;
  color: var(--text);
  font-weight: 300;
  letter-spacing: 0;
  font-feature-settings: "tnum";
  line-height: 1;
  margin-bottom: 6px;
}
.entry .e-content h4 {
  font-family: var(--serif);
  font-weight: 500;
  font-size: 21px;
  line-height: 1.45;
  letter-spacing: 0;
  margin-bottom: 12px;
  transition: color 0.2s;
  font-variation-settings: "opsz" 40;
}
.entry:hover .e-content h4 { color: var(--cyan); }
.entry .e-content .e-excerpt {
  font-size: 14px;
  color: var(--text-2);
  line-height: 1.85;
  margin-bottom: 14px;
  letter-spacing: 0.01em;
}
.entry .e-content .e-tags {
  display: flex;
  gap: 8px;
  flex-wrap: wrap;
}
.entry .e-content .e-tags span {
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  padding: 3px 8px;
  border: 1px solid var(--border-2);
  border-radius: 3px;
  color: var(--text-3);
}
.entry .e-content .e-tags span.t-news { border-color: rgba(240, 176, 97, 0.3); color: var(--amber); }
.entry .e-content .e-tags span.t-research { border-color: rgba(110, 231, 231, 0.3); color: var(--cyan); }
.entry .e-content .e-tags span.t-clinical { border-color: rgba(184, 232, 105, 0.3); color: var(--lime); }
.entry .e-content .e-tags span.t-deal { border-color: rgba(245, 138, 138, 0.3); color: var(--rose); }
.entry .e-thumb {
  aspect-ratio: 4 / 3;
  background: linear-gradient(135deg, #142340, #0E1A30);
  border-radius: 4px;
  overflow: hidden;
  position: relative;
  border: 1px solid var(--border);
}
.entry .e-thumb svg { width: 100%; height: 100%; opacity: 0.7; }
.entry .e-thumb img {
  width: 100%;
  height: 100%;
  object-fit: cover;
  display: block;
}

/* ===== Article Types ===== */
.types {
  padding: clamp(60px, 9vw, 100px) 0;
  background: linear-gradient(180deg, transparent, var(--bg-2));
}
.types-grid {
  display: grid;
  grid-template-columns: repeat(5, 1fr);
  gap: 16px;
}
.type-card {
  border: 1px solid var(--border);
  border-radius: 6px;
  padding: 26px 22px;
  background: var(--surface);
  position: relative;
  transition: all 0.3s;
  display: flex;
  flex-direction: column;
  gap: 14px;
  min-height: 280px;
  overflow: hidden;
}
.type-card::before {
  content: '';
  position: absolute;
  top: 0; left: 0;
  width: 100%; height: 2px;
  background: var(--cyan);
  transform: scaleX(0);
  transform-origin: left;
  transition: transform 0.4s;
}
.type-card:hover { transform: translateY(-3px); border-color: var(--border-2); background: var(--surface-2); }
.type-card:hover::before { transform: scaleX(1); }
.type-card .t-num {
  font-family: var(--mono);
  font-size: 11px;
  color: var(--text-4);
  letter-spacing: 0.14em;
}
.type-card .t-lat {
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  color: var(--cyan);
}
.type-card h4 {
  font-family: var(--serif);
  font-weight: 500;
  font-size: 22px;
  letter-spacing: 0;
  font-variation-settings: "opsz" 40;
  line-height: 1.3;
}
.type-card p {
  font-size: 13px;
  color: var(--text-2);
  line-height: 1.85;
  flex: 1;
  letter-spacing: 0.01em;
}
.type-card .t-link {
  font-family: var(--sans);
  font-size: 12.5px;
  letter-spacing: 0.04em;
  color: var(--cyan);
  margin-top: auto;
  display: inline-flex;
  gap: 8px;
  align-items: center;
  transition: gap 0.25s;
  font-weight: 500;
}
.type-card:hover .t-link { gap: 12px; }

/* ===== Active Targets (Round 2 addition) ===== */
.targets {
  padding: clamp(40px, 6vw, 80px) 0;
  background: linear-gradient(180deg, transparent, rgba(110, 231, 231, 0.015), transparent);
}
.targets-grid {
  display: grid;
  grid-template-columns: 200px 1fr;
  gap: 32px;
  align-items: start;
  border: 1px solid var(--border);
  border-radius: 6px;
  background: var(--surface);
  padding: 36px;
  position: relative;
  overflow: hidden;
}
.targets-grid::before {
  content: '';
  position: absolute;
  inset: 0;
  background-image:
    linear-gradient(rgba(110, 231, 231, 0.03) 1px, transparent 1px),
    linear-gradient(90deg, rgba(110, 231, 231, 0.03) 1px, transparent 1px);
  background-size: 32px 32px;
  pointer-events: none;
  mask-image: radial-gradient(ellipse 80% 80% at 70% 30%, black, transparent);
}
.targets-side { position: relative; z-index: 2; }
.targets-side .lat {
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  color: var(--cyan);
  margin-bottom: 12px;
}
.targets-side h3 {
  font-family: var(--serif);
  font-weight: 500;
  font-size: 26px;
  letter-spacing: 0;
  line-height: 1.3;
  margin-bottom: 16px;
}
.targets-side h3 em {
  font-family: var(--kai);
  font-style: normal;
  font-weight: 400;
  letter-spacing: 0.04em;
  color: var(--cyan);
  padding: 0 0.05em;
}
.targets-side p {
  font-size: 13.5px;
  color: var(--text-3);
  line-height: 1.85;
  letter-spacing: 0.01em;
  margin-bottom: 20px;
}
.targets-side .targets-legend {
  display: flex;
  flex-direction: column;
  gap: 8px;
  font-family: var(--mono);
  font-size: 10.5px;
  color: var(--text-3);
  letter-spacing: 0.1em;
  padding-top: 18px;
  border-top: 1px solid var(--border);
}
.targets-side .targets-legend span {
  display: flex; align-items: center; gap: 8px;
}
.targets-side .targets-legend .dot {
  width: 8px; height: 8px;
  border-radius: 50%;
}
.targets-side .targets-legend .dot.clinic { background: var(--lime); box-shadow: 0 0 8px var(--lime); }
.targets-side .targets-legend .dot.pre { background: var(--cyan); }
.targets-side .targets-legend .dot.early { background: var(--amber); opacity: 0.7; }

.targets-cloud { position: relative; z-index: 2; }
.target-cat {
  margin-bottom: 26px;
  padding-bottom: 20px;
  border-bottom: 1px dashed var(--border-2);
}
.target-cat:last-child { border-bottom: none; padding-bottom: 0; margin-bottom: 0; }
.target-cat-head {
  display: flex;
  align-items: baseline;
  justify-content: space-between;
  margin-bottom: 14px;
  gap: 14px;
}
.target-cat-head .cat-name {
  font-family: var(--serif);
  font-weight: 500;
  font-size: 17px;
  letter-spacing: 0;
}
.target-cat-head .cat-name .cat-en {
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  color: var(--cyan);
  margin-right: 12px;
  font-weight: 400;
}
.target-cat-head .cat-count {
  font-family: var(--mono);
  font-size: 10.5px;
  color: var(--text-3);
  letter-spacing: 0.1em;
}
.target-chips {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
}
.chip {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  padding: 7px 12px 7px 10px;
  border: 1px solid var(--border-2);
  border-radius: 999px;
  font-family: var(--mono);
  font-size: 12px;
  letter-spacing: 0.04em;
  color: var(--text-2);
  background: rgba(110, 231, 231, 0.02);
  transition: all 0.25s;
  cursor: pointer;
  position: relative;
}
.chip::before {
  content: '';
  width: 6px; height: 6px;
  border-radius: 50%;
  background: var(--text-4);
}
.chip.s-clinic::before { background: var(--lime); box-shadow: 0 0 8px var(--lime); }
.chip.s-pre::before { background: var(--cyan); }
.chip.s-early::before { background: var(--amber); opacity: 0.6; }
.chip.s-clinic { color: var(--text); border-color: rgba(184, 232, 105, 0.25); }
.chip.s-pre { border-color: rgba(110, 231, 231, 0.25); color: var(--text); }
.chip .chip-num {
  font-size: 10px;
  color: var(--text-3);
  letter-spacing: 0;
}
.chip:hover {
  border-color: var(--cyan);
  background: rgba(110, 231, 231, 0.07);
  transform: translateY(-1px);
}

/* ===== Reading Path (Round 2 addition) ===== */
.reading {
  padding: clamp(40px, 6vw, 70px) 0;
}
.reading-cards {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 18px;
}
.reading-card {
  border: 1px solid var(--border);
  border-radius: 6px;
  padding: 28px 26px 26px;
  background: var(--surface);
  position: relative;
  display: flex;
  flex-direction: column;
  gap: 14px;
  transition: all 0.3s;
}
.reading-card:hover { border-color: var(--border-2); background: var(--surface-2); }
.reading-card .persona {
  display: flex;
  align-items: center;
  gap: 12px;
  padding-bottom: 18px;
  border-bottom: 1px dashed var(--border-2);
}
.reading-card .persona-icon {
  width: 36px; height: 36px;
  border: 1px solid var(--border-2);
  border-radius: 50%;
  display: grid; place-items: center;
  background: rgba(110, 231, 231, 0.04);
}
.reading-card .persona-icon svg { width: 18px; height: 18px; stroke: var(--cyan); }
.reading-card .persona-meta .lat {
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  color: var(--text-3);
}
.reading-card .persona-meta .name {
  font-family: var(--serif);
  font-size: 18px;
  font-weight: 500;
  margin-top: 2px;
  letter-spacing: 0;
}
.reading-card .persona-meta .name em {
  font-family: var(--kai);
  font-style: normal;
  font-weight: 400;
  color: var(--cyan);
  letter-spacing: 0.04em;
  padding: 0 0.05em;
}
.reading-steps {
  list-style: none;
  display: flex;
  flex-direction: column;
  gap: 12px;
  flex: 1;
}
.reading-steps li {
  display: grid;
  grid-template-columns: 28px 1fr;
  gap: 10px;
  font-size: 13.5px;
  color: var(--text-2);
  line-height: 1.7;
  letter-spacing: 0.01em;
  align-items: baseline;
}
.reading-steps li .step-n {
  font-family: var(--mono);
  font-size: 10.5px;
  color: var(--cyan);
  letter-spacing: 0.1em;
  padding-top: 2px;
}
.reading-steps a { color: var(--text); border-bottom: 1px solid var(--border-2); transition: border-color 0.2s; }
.reading-steps a:hover { border-bottom-color: var(--cyan); color: var(--cyan); }

/* ===== CTA / community ===== */
.community {
  padding: clamp(70px, 10vw, 130px) 0;
  position: relative;
  text-align: center;
}
.community-inner {
  max-width: 780px;
  margin: 0 auto;
  position: relative;
  padding: 60px 40px;
  border: 1px solid var(--border);
  border-radius: 8px;
  background:
    radial-gradient(ellipse 80% 80% at 50% 0%, rgba(110, 231, 231, 0.08), transparent 60%),
    radial-gradient(ellipse 80% 80% at 50% 100%, rgba(184, 232, 105, 0.05), transparent 60%),
    var(--surface);
  overflow: hidden;
}
.community-inner::before, .community-inner::after {
  content: '';
  position: absolute;
  width: 1px; height: 24px;
  background: var(--cyan);
}
.community-inner::before { top: -1px; left: 30px; }
.community-inner::after { bottom: -1px; right: 30px; }
.community .eyebrow { justify-content: center; }
.community h2 {
  font-family: var(--serif);
  font-weight: 400;
  font-size: clamp(28px, 4vw, 46px);
  letter-spacing: -0.018em;
  line-height: 1.22;
  margin: 18px 0 16px;
  font-variation-settings: "opsz" 100, "SOFT" 50;
}
.community h2 em:not(.cn) { font-style: italic; color: var(--cyan); font-weight: 300; }
.community h2 em.cn {
  font-family: var(--kai);
  font-style: normal;
  font-weight: 400;
  letter-spacing: 0.05em;
  color: var(--cyan);
  padding: 0 0.06em;
}
.community p {
  font-size: 15px;
  color: var(--text-2);
  max-width: 540px;
  margin: 0 auto 30px;
  line-height: 1.85;
  letter-spacing: 0.01em;
}
.community .actions { display: flex; gap: 14px; justify-content: center; flex-wrap: wrap; }

/* ===== Footer ===== */
footer {
  border-top: 1px solid var(--border);
  padding: 70px 0 30px;
  background: var(--bg-2);
  position: relative;
  z-index: 2;
}
.foot-grid {
  display: grid;
  grid-template-columns: 2fr 1fr 1fr 1fr;
  gap: 40px;
  margin-bottom: 50px;
  padding-bottom: 40px;
  border-bottom: 1px solid var(--border);
}
.foot-brand h3 {
  font-family: var(--serif);
  font-size: 22px;
  font-weight: 500;
  margin-bottom: 14px;
  display: flex; align-items: center; gap: 12px;
}
.foot-brand p {
  font-size: 13.5px;
  color: var(--text-3);
  max-width: 320px;
  line-height: 1.85;
  margin-bottom: 20px;
  letter-spacing: 0.01em;
}
.foot-mono {
  font-family: var(--mono);
  font-size: 10.5px;
  letter-spacing: 0.18em;
  color: var(--text-4);
  text-transform: uppercase;
  display: flex; gap: 10px;
}
.foot-mono .live-tick {
  color: var(--lime);
  display: inline-flex; align-items: center; gap: 6px;
}
.foot-mono .live-tick::before {
  content: '';
  width: 5px; height: 5px;
  background: var(--lime);
  border-radius: 50%;
  animation: pulse 2s infinite;
}
.foot-col h5 {
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.18em;
  color: var(--text-3);
  text-transform: uppercase;
  margin-bottom: 18px;
}
.foot-col ul { list-style: none; display: flex; flex-direction: column; gap: 10px; }
.foot-col a {
  font-size: 13.5px;
  color: var(--text-2);
  transition: color 0.2s;
}
.foot-col a:hover { color: var(--cyan); }

.foot-bottom {
  display: flex;
  justify-content: space-between;
  font-family: var(--mono);
  font-size: 11px;
  color: var(--text-4);
  letter-spacing: 0.06em;
  flex-wrap: wrap;
  gap: 16px;
}
.foot-bottom a { color: var(--text-3); }
.foot-bottom a:hover { color: var(--cyan); }

/* ===== Animations ===== */
@keyframes float-mol {
  0%, 100% { transform: translateY(0) rotate(0deg); }
  50% { transform: translateY(-10px) rotate(2deg); }
}
@keyframes orbit {
  from { transform: rotate(0deg); }
  to { transform: rotate(360deg); }
}
@keyframes ub-pulse {
  0%, 100% { opacity: 0.4; transform: scale(0.95); }
  50% { opacity: 1; transform: scale(1.05); }
}
@keyframes ub-grow {
  0% { opacity: 0; transform: scale(0.4); }
  60% { opacity: 1; transform: scale(1); }
  100% { opacity: 1; transform: scale(1); }
}
@keyframes fadeUp {
  from { opacity: 0; transform: translateY(16px); }
  to { opacity: 1; transform: translateY(0); }
}

.hero-meta { animation: fadeUp 0.7s 0.1s backwards; }
.hero-title { animation: fadeUp 0.8s 0.2s backwards; }
.hero-sub { animation: fadeUp 0.8s 0.4s backwards; }
.hero-actions { animation: fadeUp 0.8s 0.55s backwards; }
.hero-visual { animation: fadeUp 1s 0.5s backwards; }

.molecule-system { animation: float-mol 8s ease-in-out infinite; transform-origin: center; transform-box: fill-box; }
.orbit-ring { animation: orbit 60s linear infinite; transform-origin: center; transform-box: fill-box; }
.ub-chain { transform-origin: center; transform-box: fill-box; }
.ub-1 { animation: ub-grow 0.6s 1.2s backwards, ub-pulse 3.2s 1.8s infinite; }
.ub-2 { animation: ub-grow 0.6s 1.6s backwards, ub-pulse 3.2s 2.2s infinite; }
.ub-3 { animation: ub-grow 0.6s 2.0s backwards, ub-pulse 3.2s 2.6s infinite; }

/* ===== Scroll progress bar (Round 3) ===== */
.scroll-progress {
  position: fixed;
  top: 0; left: 0;
  width: 0%; height: 2px;
  background: linear-gradient(90deg, var(--cyan), var(--lime));
  z-index: 100;
  transition: width 0.05s linear;
  box-shadow: 0 0 12px var(--cyan);
}

/* Scroll reveal — sections animate in on first viewport entry */
.reveal {
  opacity: 0;
  transform: translateY(28px);
  transition: opacity 0.9s cubic-bezier(.2,.6,.2,1), transform 0.9s cubic-bezier(.2,.6,.2,1);
  will-change: opacity, transform;
}
.reveal.in {
  opacity: 1;
  transform: translateY(0);
}
.reveal-stagger > * {
  opacity: 0;
  transform: translateY(20px);
  transition: opacity 0.7s cubic-bezier(.2,.6,.2,1), transform 0.7s cubic-bezier(.2,.6,.2,1);
}
.reveal-stagger.in > * { opacity: 1; transform: translateY(0); }
.reveal-stagger.in > *:nth-child(1) { transition-delay: 0.05s; }
.reveal-stagger.in > *:nth-child(2) { transition-delay: 0.15s; }
.reveal-stagger.in > *:nth-child(3) { transition-delay: 0.25s; }
.reveal-stagger.in > *:nth-child(4) { transition-delay: 0.35s; }
.reveal-stagger.in > *:nth-child(5) { transition-delay: 0.45s; }

/* Section page-corner mark — adds scientific paper feel to each section */
.section-mark {
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.18em;
  color: var(--text-4);
  position: absolute;
  top: clamp(20px, 3vw, 40px);
  right: var(--pad);
  z-index: 3;
  display: flex;
  align-items: center;
  gap: 8px;
}
.section-mark::before {
  content: '';
  width: 18px; height: 1px;
  background: var(--text-4);
}

/* ===== Responsive ===== */
@media (max-width: 980px) {
  .hero-grid { grid-template-columns: 1fr; }
  .hero-visual { max-width: 420px; margin: 0 auto; }
  .stats { grid-template-columns: repeat(2, 1fr); }
  .stat:nth-child(2) { border-right: none; }
  .stat:nth-child(1), .stat:nth-child(2) { border-bottom: 1px solid var(--border); }
  .lead-card { grid-template-columns: 1fr; }
  .pillars-grid { grid-template-columns: 1fr; }
  .latest-grid { grid-template-columns: 1fr; }
  .types-grid { grid-template-columns: repeat(2, 1fr); }
  .foot-grid { grid-template-columns: 1fr 1fr; }
  .nav { display: none; }
  .entry { grid-template-columns: 70px 1fr; }
  .entry .e-thumb { display: none; }
  .targets-grid { grid-template-columns: 1fr; padding: 28px; }
  .reading-cards { grid-template-columns: 1fr; }
}
@media (max-width: 560px) {
  .stats { grid-template-columns: 1fr; }
  .stat { border-right: none !important; border-bottom: 1px solid var(--border); }
  .stat:last-child { border-bottom: none; }
  .types-grid { grid-template-columns: 1fr; }
  .foot-grid { grid-template-columns: 1fr; }
  .topbar-cta { display: none; }
  .targets-grid { padding: 22px 18px; }
  .target-cat-head { flex-direction: column; align-items: start; gap: 6px; }
}


/* ============================================
   ROUND 5 · TYPOGRAPHY POLISH (all pages)
   ============================================ */

/* CSS Text Module Level 4 — automatic CJK-Latin spacing.
   Ensures proper visual gap between 中文 and Latin/digits without manual spaces.
   Modern Chromium-based browsers; degrades gracefully elsewhere. */
html {
  text-spacing-trim: space-first;
}
body {
  text-autospace: ideograph-alpha ideograph-numeric;
}

/* Make all selection visible against dark bg */
::selection {
  background: rgba(110, 231, 231, 0.35);
  color: var(--text);
}

/* Improve all link focus visibility (a11y) */
a:focus-visible,
button:focus-visible,
select:focus-visible {
  outline: 2px solid var(--cyan);
  outline-offset: 3px;
  border-radius: 2px;
}

/* Smooth-scroll for in-page anchor jumps */
html { scroll-behavior: smooth; }
@media (prefers-reduced-motion: reduce) {
  html { scroll-behavior: auto; }
  *, *::before, *::after {
    animation-duration: 0.01ms !important;
    animation-iteration-count: 1 !important;
    transition-duration: 0.01ms !important;
  }
}

/* CJK punctuation hangs off the line — improves long-form readability */
.article-body p,
.article-body li,
.arc-excerpt,
.target-summary,
.archive-hero .ah-deck,
.article-deck {
  hanging-punctuation: allow-end last;
}

/* Avoid Latin word-break inside CJK paragraphs */
.article-body p,
.article-body li {
  word-break: keep-all;
  overflow-wrap: anywhere;
}

/* Tabular figures for all monospace numbers */
.article-meta-strip .meta-data .value,
.archive-stat-row .num,
.target-fact .fact-val,
.stat-num,
.data-callout-cell .val,
.tl-event .tl-date,
.arc-date .md {
  font-variant-numeric: tabular-nums lining-nums;
  font-feature-settings: "tnum" 1, "lnum" 1;
}

/* Optical text rendering — better Chinese hinting */
body {
  text-rendering: optimizeLegibility;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}

/* Improved CJK paragraph line-height: enable text-spacing  */
.article-body p, .article-body li {
  line-break: strict;
}


/* ============================================
   BACK-TO-TOP FLOATING BUTTON (all pages)
   ============================================ */
.back-to-top {
  position: fixed;
  right: 28px; bottom: 28px;
  width: 44px; height: 44px;
  background: var(--surface);
  border: 1px solid var(--border-2);
  border-radius: 50%;
  color: var(--text-3);
  cursor: pointer;
  display: flex; align-items: center; justify-content: center;
  z-index: 90;
  opacity: 0;
  transform: translateY(8px);
  transition: opacity 0.3s, transform 0.3s, color 0.2s, border-color 0.2s, background 0.2s;
  pointer-events: none;
  backdrop-filter: blur(10px);
}
.back-to-top.show {
  opacity: 1;
  transform: translateY(0);
  pointer-events: auto;
}
.back-to-top:hover {
  color: var(--cyan);
  border-color: var(--cyan-deep);
  background: var(--surface-2);
}
.back-to-top svg { width: 16px; height: 16px; }


/* ============================================
   TOC SCROLLSPY VISUAL POLISH (single.html)
   ============================================ */
.toc li {
  transition: transform 0.25s cubic-bezier(0.2, 0.7, 0.2, 1);
}
.toc li.active {
  transform: translateX(2px);
}
.toc li::before {
  transition: opacity 0.2s, transform 0.25s cubic-bezier(0.2, 0.7, 0.2, 1);
  opacity: 0;
}
.toc li.active::before {
  opacity: 1;
  transform: scaleY(1);
}


/* ============================================
   CONSISTENT VERTICAL RHYTHM
   ============================================ */

/* Section heads — consistent gap between eyebrow and h2 across pages */
.section-head .eyebrow {
  margin-bottom: 16px !important;
}

/* Universal container padding rhythm */
.target-hero,
.article-hero,
.archive-hero {
  padding-top: clamp(64px, 8vw, 96px);
}

/* Article body bottom margin polish: avoid widows on h2 */
.article-body h2 + p,
.article-body h3 + p {
  margin-top: 0;
}

.article-body p:last-child {
  margin-bottom: 0;
}


/* ============================================
   CJK QUOTATION POLISH
   ============================================ */
/* Chinese 引号 should sit closer to text than Latin quotes do by default */
.pull-quote q {
  text-indent: -0.4em;
}


/* ============================================
   CONSISTENT HOVER & FOCUS for archive/target/single nav cards
   ============================================ */
.rel-card:focus-visible,
.arc-item:focus-visible,
.company-card:focus-visible,
.pn-cell:focus-visible {
  outline: 1px solid var(--cyan);
  outline-offset: 2px;
}


/* ============================================
   PROGRESSIVE NUMBERING for article TOC
   ============================================ */
.toc {
  counter-reset: toc;
}
.toc > li {
  counter-increment: toc;
}


/* ============================================
   IMPROVED TABLE-LIKE ROW RHYTHM (pipeline-table)
   ============================================ */
.pipeline-table .pt-row {
  transition: background 0.15s;
}
.pipeline-table .pt-row.pt-data:not(.pt-head):nth-child(even) {
  background: rgba(255, 255, 255, 0.005);
}



/* ============================================
   ROUND 6 · DETAIL POLISH
   ============================================ */

/* Custom scrollbar (WebKit & Firefox) for dark theme */
* {
  scrollbar-width: thin;
  scrollbar-color: var(--border-2) transparent;
}
*::-webkit-scrollbar {
  width: 10px;
  height: 10px;
}
*::-webkit-scrollbar-track {
  background: transparent;
}
*::-webkit-scrollbar-thumb {
  background: var(--border-2);
  border: 2px solid var(--bg);
  border-radius: 999px;
}
*::-webkit-scrollbar-thumb:hover {
  background: var(--text-4);
}

/* Skip-to-content link (a11y) */
.skip-link {
  position: absolute;
  top: -40px;
  left: 16px;
  background: var(--cyan);
  color: var(--bg);
  padding: 10px 16px;
  font-family: var(--mono);
  font-size: 12px;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  text-decoration: none;
  border-radius: 2px;
  z-index: 1000;
  transition: top 0.2s;
}
.skip-link:focus {
  top: 16px;
}

/* Topbar nav · current page indicator */
.nav a.is-current {
  color: var(--text);
  position: relative;
}
.nav a.is-current::after {
  content: '';
  position: absolute;
  left: 0; right: 0;
  bottom: -28px;
  height: 1px;
  background: var(--cyan);
  box-shadow: 0 0 6px var(--cyan);
}

/* Unified card hover timing — gentle and consistent */
.rel-card,
.arc-item,
.company-card,
.pn-cell,
.sb-target-row,
.lead-card,
.target-fact,
.pillar-card {
  transition: border-color 0.25s cubic-bezier(0.2, 0.7, 0.2, 1),
              transform 0.25s cubic-bezier(0.2, 0.7, 0.2, 1),
              background 0.25s cubic-bezier(0.2, 0.7, 0.2, 1),
              box-shadow 0.25s cubic-bezier(0.2, 0.7, 0.2, 1);
}

/* Slight transform reduction for accessibility */
.rel-card:hover,
.company-card:hover {
  transform: translateY(-1px);
}

/* Article body :first-letter — reset for Chinese first character */
/* If first char is CJK, drop-cap looks weird. Detect via :lang */
.article-body p.lead:lang(zh)::first-letter,
.article-body p.lead::first-letter {
  font-family: var(--serif);
}

/* Pull-quote — use Chinese opening quote */
:root {
  --pq-mark: '\201C';
}

/* Article body links — subtle dotted underline base */
.article-body p a {
  text-underline-offset: 4px;
  text-decoration-thickness: 1px;
}

/* Inline code in dark mode polish */
.article-body p code {
  font-feature-settings: "tnum" 1, "zero" 1;
  font-weight: 500;
}

/* Section heads — universal vertical rhythm enforcement */
.section-head {
  margin-bottom: 40px;
}
.section-head h2 {
  margin-top: 0;
}

/* Subtle entrance for back-to-top */
.back-to-top {
  box-shadow: 0 4px 24px rgba(0,0,0,0.4);
}
.back-to-top.show {
  animation: bttFloat 0.4s cubic-bezier(0.2, 0.7, 0.2, 1);
}
@keyframes bttFloat {
  from { opacity: 0; transform: translateY(12px) scale(0.92); }
  to   { opacity: 1; transform: translateY(0) scale(1); }
}

/* Article figure — subtle inner glow */
.article-figure-frame {
  box-shadow: inset 0 0 0 1px rgba(255,255,255,0.02);
}

/* Improve clickable area for sb links */
.sb-sources a, .sb-targets-arc a, .sb-target-row, .year-list a {
  position: relative;
}

/* Print stylesheet — basic */
@media print {
  body { background: white; color: black; }
  .topbar, .footer, .back-to-top, .scroll-progress, .article-aside,
  .related-section, .pn-nav, .pagination, .archive-tools, .archive-sidebar,
  .companies-block, .timeline-block { display: none !important; }
  .article-body p { color: black; font-size: 11pt; line-height: 1.7; }
  .article-title { color: black; }
}

/* High-contrast mode resilience */
@media (forced-colors: active) {
  .tag-clinical, .tag-cat, .tg, .pt-status,
  .target-aliases .alias { forced-color-adjust: auto; }
}

/* Refined arc-item hover — make thumbnail fade in slightly */
.arc-item .arc-thumb {
  transition: border-color 0.25s, opacity 0.25s;
  opacity: 0.92;
}
.arc-item:hover .arc-thumb {
  opacity: 1;
  border-color: var(--cyan-deep);
}

/* Refined topbar — slight blur on scroll  */
.topbar {
  backdrop-filter: blur(14px) saturate(140%);
  -webkit-backdrop-filter: blur(14px) saturate(140%);
}

/* Elliptic title overflow guard */
.arc-title, .rel-card h4, .pn-cell .pn-title {
  display: -webkit-box;
  -webkit-line-clamp: 3;
  -webkit-box-orient: vertical;
  overflow: hidden;
}

/* Refined input focus */
input:focus-visible, textarea:focus-visible, select:focus-visible {
  outline: 2px solid var(--cyan);
  outline-offset: 2px;
  border-color: var(--cyan-deep);
}

/* Better select chevron in dark mode */
.sort-row select {
  appearance: none;
  -webkit-appearance: none;
  background-image: url("data:image/svg+xml;utf8,<svg aria-hidden="true" xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='none' stroke='%237C8499' stroke-width='1.4'><path d='M3 6L8 11L13 6'/></svg>");
  background-repeat: no-repeat;
  background-position: right 10px center;
  background-size: 12px;
  padding-right: 30px;
}

/* Selection — ensure code blocks have fitted highlight */
code::selection { background: rgba(184, 232, 105, 0.3); }

/* Stat number alignment — keep figures rock-stable */
.archive-stat-row, .data-callout-cell .val, .target-fact .fact-val {
  font-feature-settings: "tnum" 1, "lnum" 1, "ss01" 1;
}

/* Small footer underline polish */
.footer a {
  transition: color 0.2s, border-color 0.2s;
}


/* ============================================
   SINGLE ARTICLE PAGE — long-form Chinese typography
   ============================================ */

.article-hero {
  padding: 88px 0 56px;
  border-bottom: 1px solid var(--border);
  position: relative;
  overflow: hidden;
}
.article-hero::before {
  content: '';
  position: absolute; inset: 0;
  background:
    radial-gradient(900px 400px at 80% -10%, rgba(110,231,231,0.05), transparent 60%),
    radial-gradient(600px 300px at 10% 110%, rgba(184,232,105,0.04), transparent 60%);
  pointer-events: none;
}
.article-hero > .wrap { position: relative; }

.crumbtrail {
  display: flex; align-items: center; gap: 10px;
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.15em;
  color: var(--text-3);
  text-transform: uppercase;
  margin-bottom: 28px;
}
.crumbtrail a {
  color: var(--text-3);
  text-decoration: none;
  border-bottom: 1px solid transparent;
  transition: color 0.2s, border-color 0.2s;
}
.crumbtrail a:hover { color: var(--cyan); border-bottom-color: var(--cyan); }
.crumbtrail .sep { color: var(--text-4); }
.crumbtrail .here { color: var(--text-2); }

.article-tag-row {
  display: flex; align-items: center; gap: 12px;
  flex-wrap: wrap;
  margin-bottom: 24px;
}
.article-tag-row .tag-clinical {
  display: inline-flex; align-items: center; gap: 7px;
  padding: 5px 11px;
  background: rgba(184,232,105,0.08);
  border: 1px solid rgba(184,232,105,0.3);
  color: var(--lime);
  font-family: var(--mono);
  font-size: 10.5px;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  border-radius: 2px;
}
.article-tag-row .tag-clinical::before {
  content: '';
  width: 6px; height: 6px;
  border-radius: 50%;
  background: var(--lime);
  box-shadow: 0 0 8px var(--lime);
}
.article-tag-row .tag-cat {
  font-family: var(--mono);
  font-size: 10.5px;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  color: var(--text-3);
  padding: 5px 0 5px 12px;
  border-left: 1px solid var(--border-2);
}

.article-title {
  font-family: var(--serif);
  font-weight: 400;
  font-size: clamp(34px, 4.4vw, 54px);
  line-height: 1.18;
  letter-spacing: -0.018em;
  color: var(--text);
  margin: 0 0 28px;
  max-width: 920px;
}
.article-title em {
  font-family: var(--kai);
  font-style: normal;
  background: linear-gradient(120deg, var(--cyan), var(--lime));
  -webkit-background-clip: text;
  background-clip: text;
  color: transparent;
  letter-spacing: 0.04em;
  padding: 0 0.04em;
}
.article-title .accent-num {
  font-family: var(--serif);
  font-style: italic;
  color: var(--cyan);
  letter-spacing: -0.02em;
}

.article-deck {
  font-family: var(--serif);
  font-style: italic;
  font-size: 21px;
  line-height: 1.65;
  color: var(--text-2);
  max-width: 760px;
  margin: 0 0 40px;
  letter-spacing: 0.005em;
}
.article-deck em.cn {
  font-family: var(--kai);
  font-style: normal;
  color: var(--cyan);
  letter-spacing: 0.04em;
  padding: 0 0.04em;
}

.article-meta-strip {
  display: flex; align-items: center; gap: 24px;
  padding: 18px 0;
  border-top: 1px solid var(--border);
  border-bottom: 1px solid var(--border);
  flex-wrap: wrap;
}
.meta-author {
  display: flex; align-items: center; gap: 12px;
}
.meta-author .avatar {
  width: 38px; height: 38px;
  border-radius: 50%;
  background: linear-gradient(135deg, var(--cyan-deep), var(--lime));
  display: flex; align-items: center; justify-content: center;
  font-family: var(--mono);
  font-size: 13px;
  color: var(--bg);
  font-weight: 600;
}
.meta-author .who { display: flex; flex-direction: column; gap: 2px; }
.meta-author .name {
  font-size: 13px; color: var(--text); letter-spacing: 0.02em;
}
.meta-author .role {
  font-family: var(--mono); font-size: 10px; color: var(--text-3);
  letter-spacing: 0.15em; text-transform: uppercase;
}
.meta-divider { width: 1px; height: 32px; background: var(--border-2); }
.meta-data { display: flex; flex-direction: column; gap: 3px; }
.meta-data .label {
  font-family: var(--mono); font-size: 10px; color: var(--text-3);
  letter-spacing: 0.15em; text-transform: uppercase;
}
.meta-data .value {
  font-family: var(--mono); font-size: 13px; color: var(--text);
  letter-spacing: 0.04em;
}
.meta-data.nct .value { color: var(--lime); }

.article-figure { margin: 56px 0 0; position: relative; }
.article-figure-frame {
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 4px;
  padding: 40px 40px 32px;
  position: relative; overflow: hidden;
}
.article-figure-frame::before {
  content: 'FIG. 01';
  position: absolute; top: 16px; left: 20px;
  font-family: var(--mono); font-size: 10px;
  letter-spacing: 0.2em; color: var(--text-4);
}
.article-figure svg {
  width: 100%; height: auto; display: block; max-height: 320px;
}
.article-figure figcaption {
  margin-top: 20px;
  font-family: var(--kai);
  font-size: 14px;
  color: var(--text-3);
  letter-spacing: 0.04em;
  line-height: 1.7;
  padding-left: 14px;
  border-left: 2px solid var(--cyan-deep);
}
.article-figure figcaption b { font-weight: 400; color: var(--text-2); }


/* ============================================
   ARTICLE LAYOUT (2-col: body + sticky aside)
   ============================================ */
.article-layout {
  padding: 80px 0 100px;
  display: grid;
  grid-template-columns: 1fr 280px;
  gap: 72px;
  align-items: flex-start;
}
.article-shell {
  padding: 80px var(--pad) 100px;
}
.article-grid {
  max-width: var(--max);
  margin: 0 auto;
  display: grid;
  grid-template-columns: minmax(0, 1fr) 280px;
  gap: 72px;
  align-items: flex-start;
}
.article-grid .article-body {
  max-width: 760px;
  justify-self: end;
  width: 100%;
}
.article-sidebar {
  position: sticky;
  top: 96px;
  display: flex;
  flex-direction: column;
  gap: 32px;
}
.article-layout .article-body {
  max-width: 720px;
  justify-self: end;
  width: 100%;
}
.article-aside {
  position: sticky; top: 96px;
  display: flex; flex-direction: column; gap: 32px;
}

/* article body typography */
.article-body p {
  font-family: var(--serif);
  font-size: 18px;
  line-height: 2;
  color: var(--text-2);
  margin: 0 0 1.4em;
  letter-spacing: 0.01em;
}
.article-body p.lead {
  font-size: 20px;
  color: var(--text);
  line-height: 1.85;
}
.article-body p.lead::first-letter {
  font-family: var(--serif);
  font-size: 3.4em;
  line-height: 0.9;
  float: left;
  margin: 0.06em 0.12em 0 0;
  color: var(--cyan);
  font-style: italic;
  font-weight: 400;
}
.article-body p em.cn,
.article-body em.cn {
  font-family: var(--kai); font-style: normal;
  color: var(--cyan); letter-spacing: 0.04em; padding: 0 0.04em;
}
.article-body p strong {
  font-weight: 500; color: var(--text);
  background: linear-gradient(transparent 65%, rgba(110,231,231,0.18) 65%);
  padding: 0 0.06em;
}
.article-body p code {
  font-family: var(--mono);
  font-size: 0.86em;
  background: var(--surface);
  border: 1px solid var(--border);
  padding: 1px 6px; border-radius: 2px;
  color: var(--lime); letter-spacing: 0.02em;
}
.article-body p a {
  color: var(--cyan); text-decoration: none;
  border-bottom: 1px solid var(--cyan-deep);
  transition: border-color 0.2s, color 0.2s;
}
.article-body p a:hover { color: var(--lime); border-bottom-color: var(--lime); }
.article-body sup.fn {
  font-family: var(--mono); font-size: 0.6em;
  color: var(--cyan); margin-left: 1px; cursor: help;
}

.article-body h2 {
  font-family: var(--sans);
  font-weight: 500;
  font-size: 26px;
  line-height: 1.35;
  letter-spacing: -0.01em;
  color: var(--text);
  margin: 3em 0 1em;
  padding-top: 1em;
  border-top: 1px solid var(--border);
}
.article-body h2::before {
  content: attr(data-num);
  display: block;
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.2em;
  color: var(--text-4);
  margin-bottom: 14px;
}
.article-body h2 em {
  font-family: var(--kai); font-style: normal; color: var(--cyan);
  font-weight: 400; letter-spacing: 0.04em; padding: 0 0.05em;
}
.article-body h3 {
  font-family: var(--sans); font-weight: 500;
  font-size: 18px; line-height: 1.5;
  color: var(--text); margin: 2em 0 0.8em;
}
.article-body h3 em {
  font-family: var(--kai); font-style: normal; color: var(--cyan);
  font-weight: 400; letter-spacing: 0.04em;
}

.article-body ul,
.article-body ol {
  font-family: var(--serif);
  font-size: 17.5px;
  line-height: 1.95;
  color: var(--text-2);
  padding-left: 1.4em;
  margin: 0 0 1.4em;
}
.article-body ul li,
.article-body ol li { margin-bottom: 0.4em; letter-spacing: 0.01em; }
.article-body ul li::marker { color: var(--cyan-deep); }
.article-body ol li::marker {
  color: var(--text-3); font-family: var(--mono); font-size: 0.86em;
}

/* Pull quote */
.pull-quote {
  margin: 56px -32px;
  padding: 40px 48px 40px 56px;
  background: linear-gradient(180deg, var(--surface) 0%, var(--bg-2) 100%);
  border-left: 3px solid var(--cyan);
  border-radius: 2px;
  position: relative;
}
.pull-quote::before {
  content: '\201C';
  position: absolute; top: 4px; left: 16px;
  font-family: var(--serif);
  font-size: 92px;
  color: var(--cyan-deep);
  opacity: 0.3; line-height: 1;
}
.pull-quote q {
  font-family: var(--serif);
  font-style: italic;
  font-size: 24px;
  line-height: 1.55;
  color: var(--text);
  display: block;
  quotes: none;
  letter-spacing: 0.005em;
}
.pull-quote q::before, .pull-quote q::after { content: ''; }
.pull-quote q em.cn {
  font-family: var(--kai); font-style: normal;
  color: var(--cyan); letter-spacing: 0.04em;
}
.pull-quote .pq-attr {
  display: flex; align-items: center; gap: 12px;
  margin-top: 22px; padding-top: 18px;
  border-top: 1px solid var(--border);
  font-family: var(--mono); font-size: 11px;
  letter-spacing: 0.15em; color: var(--text-3);
  text-transform: uppercase;
}
.pull-quote .pq-attr::before {
  content: ''; width: 24px; height: 1px; background: var(--cyan-deep);
}

/* Inline figure / data callout */
.inline-figure {
  margin: 48px 0;
  background: var(--bg-2);
  border: 1px solid var(--border);
  border-radius: 3px; overflow: hidden;
}
.inline-figure-head {
  padding: 14px 22px;
  border-bottom: 1px solid var(--border);
  display: flex; justify-content: space-between; align-items: center;
  background: var(--surface);
}
.inline-figure-head .ft {
  font-family: var(--mono); font-size: 10px;
  letter-spacing: 0.2em; text-transform: uppercase; color: var(--text-3);
}
.inline-figure-head .src {
  font-family: var(--mono); font-size: 10px;
  letter-spacing: 0.1em; color: var(--text-4);
}
.inline-figure-body { padding: 32px; }
.inline-figure-caption {
  padding: 16px 22px;
  border-top: 1px solid var(--border);
  font-family: var(--kai);
  font-size: 13.5px; color: var(--text-3);
  line-height: 1.75; letter-spacing: 0.04em;
}

/* Data callout panel */
.data-callout {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 0;
  margin: 40px 0;
  border: 1px solid var(--border);
  border-radius: 3px;
  overflow: hidden;
  background: var(--surface);
}
.data-callout-cell {
  padding: 24px 22px;
  border-right: 1px solid var(--border);
  position: relative;
}
.data-callout-cell:last-child { border-right: none; }
.data-callout-cell .lbl {
  font-family: var(--mono); font-size: 9.5px;
  letter-spacing: 0.2em; text-transform: uppercase;
  color: var(--text-3); margin-bottom: 12px;
}
.data-callout-cell .val {
  font-family: var(--serif); font-style: italic;
  font-size: 32px; line-height: 1;
  color: var(--text); letter-spacing: -0.02em;
  margin-bottom: 6px;
}
.data-callout-cell .val .unit {
  font-family: var(--mono); font-size: 13px;
  font-style: normal; color: var(--text-3);
  margin-left: 4px; letter-spacing: 0.05em;
}
.data-callout-cell .desc {
  font-family: var(--kai); font-size: 12px;
  color: var(--text-3); line-height: 1.7; letter-spacing: 0.04em;
}

/* References list */
.refs-list {
  margin: 48px 0 0;
  padding: 28px 0 0;
  border-top: 1px solid var(--border);
}
.refs-list .refs-head {
  font-family: var(--mono); font-size: 11px;
  letter-spacing: 0.2em; text-transform: uppercase;
  color: var(--text-3); margin-bottom: 18px;
}
.refs-list ol {
  list-style: none; padding: 0; margin: 0;
  counter-reset: ref;
}
.refs-list ol li {
  counter-increment: ref;
  padding: 12px 0 12px 36px;
  border-bottom: 1px solid var(--border);
  position: relative;
  font-family: var(--sans);
  font-size: 13.5px; line-height: 1.7;
  color: var(--text-3); letter-spacing: 0.01em;
}
.refs-list ol li:last-child { border-bottom: none; }
.refs-list ol li::before {
  content: '[' counter(ref) ']';
  position: absolute; left: 0; top: 12px;
  font-family: var(--mono); font-size: 10px;
  letter-spacing: 0.1em; color: var(--cyan);
}
.refs-list ol li a {
  color: var(--text-2); text-decoration: none;
  border-bottom: 1px solid transparent;
}
.refs-list ol li a:hover {
  color: var(--cyan); border-bottom-color: var(--cyan);
}
.refs-list ol li .src-ft {
  font-family: var(--mono); font-size: 10px;
  letter-spacing: 0.12em; color: var(--text-4);
  margin-left: 8px; text-transform: uppercase;
}


/* ============================================
   SIDEBAR
   ============================================ */
.sidebar-block,
.sb-block {
  border-top: 1px solid var(--border);
  padding-top: 18px;
}
.sidebar-block .sb-head,
.sb-block .sb-head {
  font-family: var(--mono); font-size: 10px;
  letter-spacing: 0.22em; text-transform: uppercase;
  color: var(--text-3); margin-bottom: 14px;
}

.sb-list {
  list-style: none;
  padding: 0;
  margin: 0;
  display: flex;
  flex-direction: column;
  gap: 1px;
}
.sb-list li {
  margin: 0;
}
.sb-list a {
  display: flex;
  justify-content: space-between;
  gap: 14px;
  padding: 10px 0;
  border-bottom: 1px solid var(--border);
  color: var(--text-3);
  text-decoration: none;
  font-family: var(--sans);
  font-size: 13px;
  line-height: 1.55;
  letter-spacing: 0.01em;
  transition: color 0.2s, padding-left 0.2s;
}
.sb-list li:last-child a {
  border-bottom: 0;
}
.sb-list a:hover {
  color: var(--cyan);
  padding-left: 6px;
}

.toc {
  list-style: none; padding: 0; margin: 0;
  display: flex; flex-direction: column; gap: 10px;
  border-left: 1px solid var(--border);
  padding-left: 14px;
}
.toc li { position: relative; }
.toc li a {
  font-family: var(--sans); font-size: 13px; line-height: 1.5;
  color: var(--text-3); text-decoration: none;
  display: block; padding: 4px 0;
  letter-spacing: 0.01em; transition: color 0.2s;
}
.toc li a:hover { color: var(--text-2); }
.toc li.active a { color: var(--cyan); }
.toc li.active::before {
  content: '';
  position: absolute; left: -15px; top: 8px;
  width: 1px; height: 16px;
  background: var(--cyan);
  box-shadow: 0 0 6px var(--cyan);
}
.toc li.depth-2 a {
  padding-left: 12px; font-size: 12px; color: var(--text-4);
}
.toc li.depth-2 a:hover { color: var(--text-3); }

.sb-targets { display: flex; flex-direction: column; gap: 8px; }
.sb-target-row {
  display: flex; justify-content: space-between; align-items: center;
  padding: 10px 12px;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 2px;
  text-decoration: none;
  transition: border-color 0.2s, background 0.2s;
}
.sb-target-row:hover {
  border-color: var(--cyan-deep); background: var(--surface-2);
}
.sb-target-row .sb-target-name {
  font-family: var(--mono); font-size: 12.5px;
  color: var(--text); letter-spacing: 0.04em;
}
.sb-target-row .sb-target-meta {
  font-family: var(--mono); font-size: 9.5px;
  color: var(--text-3); letter-spacing: 0.1em; text-transform: uppercase;
}

.sb-sources { display: flex; flex-direction: column; gap: 1px; }
.sb-sources a {
  font-family: var(--sans); font-size: 12.5px;
  color: var(--text-3); text-decoration: none;
  padding: 8px 0;
  border-bottom: 1px solid var(--border);
  display: flex; justify-content: space-between; align-items: center;
  letter-spacing: 0.01em;
}
.sb-sources a:last-child { border-bottom: none; }
.sb-sources a:hover { color: var(--cyan); }
.sb-sources a span.host {
  font-family: var(--mono); font-size: 10px;
  color: var(--text-4); letter-spacing: 0.1em;
}

/* article foot */
.article-foot {
  margin-top: 64px;
  padding-top: 32px;
  border-top: 1px solid var(--border-2);
  display: flex; justify-content: space-between; align-items: center;
  flex-wrap: wrap; gap: 24px;
}
.article-tags { display: flex; gap: 8px; flex-wrap: wrap; }
.article-tags a {
  font-family: var(--mono); font-size: 10.5px;
  letter-spacing: 0.18em; text-transform: uppercase;
  color: var(--text-3);
  padding: 7px 12px;
  border: 1px solid var(--border);
  border-radius: 2px;
  text-decoration: none;
  transition: all 0.2s;
}
.article-tags a:hover {
  color: var(--cyan); border-color: var(--cyan-deep);
  background: rgba(110,231,231,0.05);
}
.article-tags a::before {
  content: '#'; margin-right: 4px; color: var(--text-4);
}
.share-row { display: flex; gap: 6px; }
.share-row button {
  width: 36px; height: 36px;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 2px;
  color: var(--text-3);
  cursor: pointer;
  display: flex; align-items: center; justify-content: center;
  transition: all 0.2s;
}
.share-row button:hover { color: var(--cyan); border-color: var(--cyan-deep); }
.share-row button svg { width: 14px; height: 14px; }

/* related articles */
.related-section {
  padding: 80px 0 60px;
  border-top: 1px solid var(--border);
  background: var(--bg-2);
}
.related-section .section-head { margin-bottom: 40px; }
.related-row {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 24px;
}
.rel-card {
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 3px;
  padding: 28px 24px;
  text-decoration: none;
  transition: border-color 0.3s, transform 0.3s;
  display: flex; flex-direction: column; gap: 16px;
  height: 100%;
}
.rel-card:hover { border-color: var(--cyan-deep); transform: translateY(-2px); }
.rel-card .rel-tag {
  font-family: var(--mono); font-size: 10px;
  letter-spacing: 0.18em; text-transform: uppercase; color: var(--cyan);
}
.rel-card h4 {
  font-family: var(--serif); font-weight: 400;
  font-size: 19px; line-height: 1.4;
  letter-spacing: -0.005em; color: var(--text); margin: 0;
}
.rel-card h4 em {
  font-family: var(--kai); font-style: normal;
  color: var(--cyan); letter-spacing: 0.04em;
}
.rel-card p {
  font-family: var(--sans); font-size: 13px;
  line-height: 1.7; color: var(--text-3);
  margin: 0; letter-spacing: 0.01em;
}
.rel-card .rel-meta {
  margin-top: auto; padding-top: 16px;
  border-top: 1px solid var(--border);
  display: flex; justify-content: space-between;
  font-family: var(--mono); font-size: 10px;
  letter-spacing: 0.12em; color: var(--text-4); text-transform: uppercase;
}

/* Prev / Next nav */
.pn-nav {
  padding: 56px 0 40px;
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 24px;
  border-top: 1px solid var(--border);
}
.pn-cell {
  padding: 24px 28px;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 3px;
  text-decoration: none;
  transition: border-color 0.2s, background 0.2s;
}
.pn-cell:hover { border-color: var(--cyan-deep); background: var(--surface-2); }
.pn-cell .dir {
  font-family: var(--mono); font-size: 10px;
  letter-spacing: 0.2em; text-transform: uppercase;
  color: var(--text-3); margin-bottom: 10px;
  display: flex; align-items: center; gap: 8px;
}
.pn-cell .pn-title {
  font-family: var(--serif); font-size: 17px; line-height: 1.45;
  color: var(--text); letter-spacing: -0.005em;
}
.pn-cell .pn-title em {
  font-family: var(--kai); font-style: normal;
  color: var(--cyan); letter-spacing: 0.04em;
}
.pn-cell.next { text-align: right; }
.pn-cell.next .dir { justify-content: flex-end; }

/* responsive */
@media (max-width: 980px) {
  .article-layout {
    grid-template-columns: 1fr;
    gap: 56px;
    padding: 60px 0 80px;
  }
  .article-shell {
    padding: 60px var(--pad) 80px;
  }
  .article-grid {
    grid-template-columns: 1fr;
    gap: 48px;
  }
  .article-grid .article-body {
    justify-self: stretch;
    max-width: none;
  }
  .article-sidebar {
    position: static;
    border-top: 1px solid var(--border);
    padding-top: 40px;
  }
  .article-aside {
    position: static; order: 2;
    border-top: 1px solid var(--border);
    padding-top: 40px;
  }
  .article-layout .article-body {
    justify-self: stretch; max-width: none;
  }
  .data-callout { grid-template-columns: repeat(2, 1fr); }
  .data-callout-cell:nth-child(2) { border-right: none; }
  .related-row { grid-template-columns: 1fr; }
  .pn-nav { grid-template-columns: 1fr; }
  .pull-quote { margin-left: 0; margin-right: 0; }
}

@media (max-width: 640px) {
  .article-hero { padding: 56px 0 36px; }
  .article-title { font-size: 30px; }
  .article-deck { font-size: 17px; }
  .article-body p { font-size: 16.5px; line-height: 1.9; }
  .article-body p.lead { font-size: 18px; }
  .article-body h2 { font-size: 22px; }
  .data-callout { grid-template-columns: 1fr; }
  .data-callout-cell { border-right: none; border-bottom: 1px solid var(--border); }
  .data-callout-cell:last-child { border-bottom: none; }
  .pull-quote { padding: 28px 24px 28px 32px; margin: 36px 0; }
  .pull-quote q { font-size: 19px; }
  .article-meta-strip { gap: 14px; }
  .meta-divider { display: none; }
}



/* ============================================
   ARCHIVE / CATEGORY PAGE
   ============================================ */

.archive-hero {
  padding: 84px 0 48px;
  border-bottom: 1px solid var(--border);
  position: relative;
  overflow: hidden;
}
.archive-hero::before {
  content: '';
  position: absolute; inset: 0;
  background: radial-gradient(800px 350px at 90% 0%, rgba(110,231,231,0.05), transparent 60%);
  pointer-events: none;
}
.archive-hero > .wrap { position: relative; }

.archive-hero .ah-grid {
  display: grid;
  grid-template-columns: 1fr auto;
  gap: 48px;
  align-items: end;
}
.archive-hero .ah-title {
  font-family: var(--serif);
  font-weight: 400;
  font-size: clamp(40px, 5.2vw, 68px);
  line-height: 1.08;
  letter-spacing: -0.022em;
  color: var(--text);
  margin: 12px 0 0;
}
.archive-hero .ah-title em {
  font-family: var(--kai);
  font-style: normal;
  background: linear-gradient(120deg, var(--cyan), var(--lime));
  -webkit-background-clip: text;
  background-clip: text;
  color: transparent;
  letter-spacing: 0.04em;
}
.archive-hero .ah-deck {
  font-family: var(--serif);
  font-style: italic;
  font-size: 19px;
  line-height: 1.65;
  color: var(--text-2);
  max-width: 600px;
  margin: 24px 0 0;
  letter-spacing: 0.005em;
}
.archive-hero .ah-deck em.cn {
  font-family: var(--kai);
  font-style: normal;
  color: var(--cyan);
  letter-spacing: 0.04em;
}

.archive-stats {
  display: flex; flex-direction: column;
  gap: 14px;
  padding-left: 32px;
  border-left: 1px solid var(--border);
  min-width: 240px;
}
.archive-stat-row {
  display: flex; justify-content: space-between; align-items: baseline;
  gap: 16px;
}
.archive-stat-row .lab {
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  color: var(--text-3);
}
.archive-stat-row .num {
  font-family: var(--serif);
  font-style: italic;
  font-size: 22px;
  color: var(--text);
  letter-spacing: -0.02em;
}
.archive-stat-row .num .unit {
  font-family: var(--mono);
  font-size: 10px;
  font-style: normal;
  color: var(--text-3);
  margin-left: 4px;
  letter-spacing: 0.1em;
}

/* tools / filter bar */
.archive-tools {
  padding: 28px 0;
  border-bottom: 1px solid var(--border);
  display: flex; justify-content: space-between; align-items: center;
  flex-wrap: wrap; gap: 16px;
}
.filter-row {
  display: flex; gap: 8px;
  flex-wrap: wrap;
}
.chip-f {
  padding: 7px 14px;
  background: transparent;
  border: 1px solid var(--border);
  border-radius: 999px;
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--text-3);
  cursor: pointer;
  transition: all 0.2s;
}
.chip-f:hover { border-color: var(--cyan-deep); color: var(--text); }
.chip-f.active {
  background: rgba(110,231,231,0.08);
  border-color: var(--cyan);
  color: var(--cyan);
}
.chip-f .count {
  margin-left: 6px;
  color: var(--text-4);
  font-size: 10px;
}
.chip-f.active .count { color: var(--cyan-deep); }

.sort-row {
  display: flex; align-items: center; gap: 12px;
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--text-3);
}
.sort-row select {
  background: var(--surface);
  border: 1px solid var(--border);
  color: var(--text-2);
  padding: 7px 12px;
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.08em;
  border-radius: 2px;
  cursor: pointer;
}


/* ============================================
   ARCHIVE LAYOUT
   ============================================ */
.archive-layout {
  padding: 48px 0 80px;
  display: grid;
  grid-template-columns: 1fr 280px;
  gap: 64px;
  align-items: flex-start;
}

.arc-list { display: flex; flex-direction: column; }

.arc-item {
  display: grid;
  grid-template-columns: 110px 1fr 200px;
  gap: 32px;
  padding: 32px 0;
  border-bottom: 1px solid var(--border);
  text-decoration: none;
  align-items: start;
  transition: background 0.2s;
}
.arc-item:hover { background: rgba(110,231,231,0.02); }
.arc-item:hover .arc-title { color: var(--cyan); }
.arc-item:first-child { padding-top: 0; }
.arc-item:last-child { border-bottom: none; }

.arc-date {
  font-family: var(--mono);
  display: flex; flex-direction: column; gap: 6px;
  padding-top: 4px;
}
.arc-date .yr {
  font-size: 11px;
  letter-spacing: 0.18em;
  color: var(--text-4);
}
.arc-date .md {
  font-family: var(--serif);
  font-style: italic;
  font-size: 26px;
  color: var(--text);
  letter-spacing: -0.02em;
  line-height: 1;
}
.arc-date .read {
  margin-top: 4px;
  font-size: 9.5px;
  letter-spacing: 0.15em;
  text-transform: uppercase;
  color: var(--text-3);
}

.arc-content {
  display: flex; flex-direction: column;
  gap: 12px;
}
.arc-tag-row {
  display: flex; gap: 8px;
  flex-wrap: wrap;
}
.arc-tag-row .tg {
  display: inline-flex; align-items: center;
  font-family: var(--mono);
  font-size: 9.5px;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  color: var(--text-3);
  padding: 3px 8px;
  border: 1px solid var(--border-2);
  border-radius: 2px;
}
.arc-tag-row .tg.tg-clinical {
  color: var(--lime); border-color: rgba(184,232,105,0.3);
  background: rgba(184,232,105,0.05);
}
.arc-tag-row .tg.tg-research {
  color: var(--cyan); border-color: rgba(110,231,231,0.3);
  background: rgba(110,231,231,0.05);
}
.arc-tag-row .tg.tg-deals {
  color: var(--rose); border-color: rgba(245,138,138,0.3);
  background: rgba(245,138,138,0.05);
}
.arc-tag-row .tg.tg-news {
  color: var(--amber); border-color: rgba(240,176,97,0.3);
  background: rgba(240,176,97,0.05);
}

.arc-title {
  font-family: var(--serif);
  font-weight: 400;
  font-size: 24px;
  line-height: 1.32;
  letter-spacing: -0.005em;
  color: var(--text);
  margin: 0;
  transition: color 0.2s;
}
.arc-title em {
  font-family: var(--kai);
  font-style: normal;
  color: var(--cyan);
  letter-spacing: 0.04em;
  padding: 0 0.04em;
}
.arc-excerpt {
  font-family: var(--sans);
  font-size: 13.5px;
  line-height: 1.75;
  color: var(--text-3);
  margin: 0;
  letter-spacing: 0.01em;
  display: -webkit-box;
  -webkit-line-clamp: 2;
  -webkit-box-orient: vertical;
  overflow: hidden;
}
.arc-foot {
  display: flex; align-items: center; gap: 14px;
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--text-4);
  margin-top: 4px;
}
.arc-foot .author { color: var(--text-3); }
.arc-foot .target-pill {
  padding: 2px 8px;
  border: 1px solid var(--border);
  border-radius: 2px;
  color: var(--cyan-deep);
  font-size: 9.5px;
}

.arc-thumb {
  background: var(--bg-2);
  border: 1px solid var(--border);
  border-radius: 2px;
  height: 120px;
  position: relative;
  overflow: hidden;
}
.arc-thumb-svg { position: absolute; inset: 0; width: 100%; height: 100%; }
.arc-thumb-label {
  position: absolute; bottom: 8px; left: 10px;
  font-family: var(--mono);
  font-size: 8.5px;
  letter-spacing: 0.15em;
  text-transform: uppercase;
  color: var(--text-4);
}

/* pagination */
.pagination {
  margin-top: 56px;
  display: flex; justify-content: center; align-items: center;
  gap: 6px;
}
.pg-btn {
  min-width: 36px; height: 36px;
  padding: 0 10px;
  background: transparent;
  border: 1px solid var(--border);
  border-radius: 2px;
  color: var(--text-3);
  cursor: pointer;
  font-family: var(--mono);
  font-size: 12px;
  letter-spacing: 0.05em;
  display: flex; align-items: center; justify-content: center;
  transition: all 0.2s;
  text-decoration: none;
}
.pg-btn:hover { border-color: var(--cyan-deep); color: var(--text); }
.pg-btn.active {
  background: rgba(110,231,231,0.08);
  border-color: var(--cyan);
  color: var(--cyan);
}
.pg-btn.disabled { opacity: 0.3; cursor: not-allowed; }
.pg-ellipsis {
  color: var(--text-4); padding: 0 6px;
  font-family: var(--mono);
}

/* archive sidebar */
.archive-sidebar {
  position: sticky;
  top: 96px;
  display: flex; flex-direction: column;
  gap: 32px;
}
.sb-head-archive {
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.22em;
  text-transform: uppercase;
  color: var(--text-3);
  margin-bottom: 16px;
  padding-bottom: 12px;
  border-bottom: 1px solid var(--border);
}

.sb-targets-arc { display: flex; flex-direction: column; gap: 1px; }
.sb-targets-arc a {
  display: flex; justify-content: space-between; align-items: center;
  padding: 12px 0;
  text-decoration: none;
  border-bottom: 1px solid var(--border);
  transition: padding-left 0.2s;
}
.sb-targets-arc a:hover { padding-left: 6px; }
.sb-targets-arc a:hover .name { color: var(--cyan); }
.sb-targets-arc a:last-child { border-bottom: none; }
.sb-targets-arc .name {
  font-family: var(--mono);
  font-size: 13px;
  color: var(--text);
  letter-spacing: 0.04em;
  transition: color 0.2s;
}
.sb-targets-arc .meta {
  display: flex; align-items: center; gap: 8px;
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--text-3);
}
.sb-targets-arc .meta .dot {
  width: 6px; height: 6px;
  border-radius: 50%;
}
.sb-targets-arc .meta .dot.s-clinic { background: var(--lime); }
.sb-targets-arc .meta .dot.s-pre { background: var(--cyan); }
.sb-targets-arc .meta .dot.s-early { background: var(--text-4); }

.year-list { display: flex; flex-direction: column; }
.year-list a {
  display: flex; justify-content: space-between;
  padding: 10px 0;
  border-bottom: 1px solid var(--border);
  text-decoration: none;
  font-family: var(--mono);
  font-size: 12px;
  color: var(--text-3);
  letter-spacing: 0.05em;
  transition: color 0.2s;
}
.year-list a:hover { color: var(--cyan); }
.year-list a:last-child { border-bottom: none; }
.year-list .yr-num {
  font-family: var(--serif);
  font-style: italic;
  font-size: 16px;
  color: var(--text);
  letter-spacing: -0.02em;
}
.year-list .yr-count { color: var(--text-4); }

.featured-author {
  padding: 24px 22px;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 3px;
}
.featured-author .fa-name {
  font-family: var(--kai);
  font-size: 18px;
  color: var(--text);
  letter-spacing: 0.04em;
  margin-bottom: 8px;
}
.featured-author .fa-role {
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  color: var(--cyan);
  margin-bottom: 14px;
}
.featured-author .fa-bio {
  font-family: var(--serif);
  font-style: italic;
  font-size: 13px;
  line-height: 1.7;
  color: var(--text-3);
  letter-spacing: 0.005em;
}
.featured-author .fa-stats {
  margin-top: 18px;
  padding-top: 14px;
  border-top: 1px solid var(--border);
  display: flex; justify-content: space-between;
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--text-3);
}
.featured-author .fa-stats em {
  font-family: var(--serif);
  font-size: 16px;
  color: var(--text);
  font-style: italic;
  letter-spacing: -0.02em;
  margin-right: 4px;
}

/* responsive */
@media (max-width: 980px) {
  .archive-hero .ah-grid { grid-template-columns: 1fr; gap: 32px; }
  .archive-stats {
    border-left: none;
    border-top: 1px solid var(--border);
    padding-left: 0;
    padding-top: 24px;
    flex-direction: row;
    flex-wrap: wrap;
    gap: 24px 32px;
  }
  .archive-layout { grid-template-columns: 1fr; gap: 56px; }
  .archive-sidebar {
    position: static; order: 2;
    border-top: 1px solid var(--border);
    padding-top: 40px;
  }
  .arc-item { grid-template-columns: 90px 1fr; }
  .arc-thumb { display: none; }
}
@media (max-width: 640px) {
  .archive-hero { padding: 56px 0 32px; }
  .arc-item {
    grid-template-columns: 1fr;
    gap: 14px;
    padding: 24px 0;
  }
  .arc-date { flex-direction: row; align-items: baseline; gap: 10px; }
  .arc-date .md { font-size: 18px; }
  .arc-title { font-size: 20px; }
  .archive-tools { padding: 20px 0; }
}



/* ============================================
   TARGET DOSSIER PAGE
   ============================================ */

.target-hero {
  padding: 96px 0 72px;
  position: relative;
  overflow: hidden;
  border-bottom: 1px solid var(--border);
}
.target-hero::before {
  content: '';
  position: absolute; inset: 0;
  background:
    radial-gradient(700px 400px at 80% 0%, rgba(110,231,231,0.08), transparent 60%),
    radial-gradient(500px 300px at 0% 100%, rgba(184,232,105,0.06), transparent 60%);
  pointer-events: none;
}
.target-hero > .wrap { position: relative; }

.target-mono-id {
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.25em;
  text-transform: uppercase;
  color: var(--text-3);
  margin-bottom: 20px;
  display: flex; align-items: center; gap: 14px;
}
.target-mono-id .dot {
  width: 7px; height: 7px;
  border-radius: 50%;
  background: var(--lime);
  box-shadow: 0 0 8px var(--lime);
}
.target-mono-id .sep {
  width: 24px; height: 1px;
  background: var(--border-2);
}
.target-mono-id .stat-tag {
  color: var(--lime);
  font-weight: 500;
}

.target-name {
  font-family: var(--serif);
  font-weight: 400;
  font-size: clamp(60px, 9vw, 140px);
  line-height: 0.95;
  letter-spacing: -0.04em;
  color: var(--text);
  margin: 0 0 24px;
  display: flex; align-items: baseline;
  gap: 24px;
  flex-wrap: wrap;
}
.target-name .greek {
  font-family: var(--serif);
  font-style: italic;
  background: linear-gradient(135deg, var(--cyan), var(--lime));
  -webkit-background-clip: text;
  background-clip: text;
  color: transparent;
  letter-spacing: -0.04em;
}
.target-name .target-cn {
  font-family: var(--kai);
  font-style: normal;
  font-size: 0.42em;
  font-weight: 400;
  color: var(--text-3);
  letter-spacing: 0.06em;
  align-self: flex-end;
  padding-bottom: 0.3em;
}

.target-aliases {
  display: flex; gap: 8px;
  flex-wrap: wrap;
  margin-bottom: 28px;
}
.target-aliases .alias {
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.12em;
  color: var(--text-3);
  padding: 5px 11px;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 2px;
}
.target-aliases .alias.gene {
  color: var(--cyan);
  border-color: rgba(110,231,231,0.2);
  background: rgba(110,231,231,0.04);
}

.target-summary {
  font-family: var(--serif);
  font-style: italic;
  font-size: 21px;
  line-height: 1.6;
  color: var(--text-2);
  max-width: 780px;
  letter-spacing: 0.005em;
  margin: 0 0 56px;
}
.target-summary em.cn {
  font-family: var(--kai);
  font-style: normal;
  color: var(--cyan);
  letter-spacing: 0.04em;
}

/* Key facts grid */
.target-facts {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 0;
  border: 1px solid var(--border);
  border-radius: 3px;
  overflow: hidden;
  background: var(--surface);
}
.target-fact {
  padding: 28px 26px;
  border-right: 1px solid var(--border);
  position: relative;
}
.target-fact:last-child { border-right: none; }
.target-fact .fact-lab {
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.2em;
  text-transform: uppercase;
  color: var(--text-3);
  margin-bottom: 14px;
}
.target-fact .fact-val {
  font-family: var(--serif);
  font-style: italic;
  font-size: 38px;
  line-height: 1;
  color: var(--text);
  letter-spacing: -0.02em;
  margin-bottom: 10px;
}
.target-fact .fact-val .small {
  font-size: 0.45em;
  color: var(--text-3);
  margin-left: 6px;
  letter-spacing: 0;
}
.target-fact .fact-val.lime { color: var(--lime); }
.target-fact .fact-val.cyan { color: var(--cyan); }
.target-fact .fact-desc {
  font-family: var(--kai);
  font-size: 12.5px;
  color: var(--text-3);
  line-height: 1.7;
  letter-spacing: 0.04em;
}


/* ============================================
   PIPELINE TABLE
   ============================================ */
.pipeline-block {
  padding: 96px 0 56px;
  border-bottom: 1px solid var(--border);
}
.pipeline-table {
  margin-top: 40px;
  border: 1px solid var(--border);
  border-radius: 3px;
  overflow: hidden;
  background: var(--bg);
}
.pipeline-table .pt-row {
  display: grid;
  grid-template-columns: 200px 160px 1fr 140px 100px;
  gap: 24px;
  padding: 20px 28px;
  border-bottom: 1px solid var(--border);
  align-items: center;
}
.pipeline-table .pt-row:last-child { border-bottom: none; }
.pipeline-table .pt-row.pt-head {
  background: var(--surface);
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.2em;
  text-transform: uppercase;
  color: var(--text-3);
  padding: 14px 28px;
}
.pipeline-table .pt-row.pt-data {
  transition: background 0.2s;
}
.pipeline-table .pt-row.pt-data:hover {
  background: rgba(110,231,231,0.02);
}

.pt-mol {
  font-family: var(--mono);
  font-size: 14px;
  color: var(--text);
  letter-spacing: 0.04em;
  display: flex; flex-direction: column; gap: 4px;
}
.pt-mol .mol-sub {
  font-family: var(--kai);
  font-size: 11.5px;
  color: var(--text-3);
  letter-spacing: 0.04em;
}
.pt-company {
  font-family: var(--sans);
  font-size: 13px;
  color: var(--text-2);
  letter-spacing: 0.02em;
}

/* phase bar */
.phase-bar {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 2px;
  height: 8px;
}
.phase-bar .ph {
  background: var(--surface-2);
  border-radius: 1px;
  position: relative;
}
.phase-bar .ph.done { background: var(--cyan-deep); }
.phase-bar .ph.current {
  background: linear-gradient(90deg, var(--cyan-deep), var(--lime));
}
.phase-bar .ph.current::after {
  content: '';
  position: absolute;
  right: -1px; top: -2px;
  width: 4px; height: 12px;
  background: var(--lime);
  box-shadow: 0 0 6px var(--lime);
}
.phase-label {
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.15em;
  text-transform: uppercase;
  color: var(--text-3);
  margin-top: 8px;
}
.phase-label.lime { color: var(--lime); }

.pt-indication {
  font-family: var(--sans);
  font-size: 12.5px;
  line-height: 1.5;
  color: var(--text-3);
  letter-spacing: 0.01em;
}
.pt-indication strong {
  color: var(--text-2);
  font-weight: 500;
  display: block;
  margin-bottom: 2px;
}
.pt-status {
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.15em;
  text-transform: uppercase;
  padding: 5px 10px;
  border-radius: 2px;
  text-align: center;
}
.pt-status.live {
  color: var(--lime);
  background: rgba(184,232,105,0.08);
  border: 1px solid rgba(184,232,105,0.3);
}
.pt-status.paused {
  color: var(--amber);
  background: rgba(240,176,97,0.06);
  border: 1px solid rgba(240,176,97,0.25);
}
.pt-status.preclin {
  color: var(--cyan);
  background: rgba(110,231,231,0.06);
  border: 1px solid rgba(110,231,231,0.25);
}


/* ============================================
   COMPANIES GRID
   ============================================ */
.companies-block {
  padding: 96px 0 56px;
  border-bottom: 1px solid var(--border);
  background: var(--bg-2);
}
.companies-grid {
  margin-top: 40px;
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 16px;
}
.company-card {
  padding: 24px 22px;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 3px;
  text-decoration: none;
  display: flex; flex-direction: column;
  gap: 14px;
  transition: border-color 0.3s, transform 0.3s;
  position: relative;
  overflow: hidden;
}
.company-card:hover {
  border-color: var(--cyan-deep);
  transform: translateY(-2px);
}
.company-card .cc-name {
  font-family: var(--serif);
  font-style: italic;
  font-size: 22px;
  color: var(--text);
  letter-spacing: -0.005em;
  line-height: 1.2;
}
.company-card .cc-tick {
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.18em;
  color: var(--cyan);
  margin-top: -6px;
}
.company-card .cc-position {
  font-family: var(--kai);
  font-size: 13px;
  color: var(--text-2);
  line-height: 1.7;
  letter-spacing: 0.04em;
  margin-top: auto;
}
.company-card .cc-stats {
  display: flex; justify-content: space-between;
  padding-top: 14px;
  border-top: 1px solid var(--border);
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--text-3);
}
.company-card .cc-stats em {
  font-family: var(--serif);
  font-style: italic;
  font-size: 14px;
  color: var(--text);
  letter-spacing: -0.02em;
  margin-right: 4px;
}


/* ============================================
   TIMELINE
   ============================================ */
.timeline-block {
  padding: 96px 0;
  position: relative;
}
.timeline-track {
  margin-top: 56px;
  position: relative;
  padding-left: 32px;
}
.timeline-track::before {
  content: '';
  position: absolute;
  left: 7px; top: 8px; bottom: 8px;
  width: 1px;
  background: linear-gradient(180deg, var(--cyan-deep), var(--border) 80%);
}
.tl-event {
  position: relative;
  padding: 0 0 36px 36px;
}
.tl-event:last-child { padding-bottom: 0; }
.tl-event::before {
  content: '';
  position: absolute;
  left: -32px; top: 4px;
  width: 16px; height: 16px;
  border-radius: 50%;
  background: var(--bg);
  border: 1px solid var(--cyan-deep);
}
.tl-event.major::before {
  background: var(--cyan);
  box-shadow: 0 0 10px rgba(110,231,231,0.5);
}
.tl-event .tl-date {
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  color: var(--text-3);
  margin-bottom: 10px;
}
.tl-event.major .tl-date { color: var(--cyan); }
.tl-event .tl-title {
  font-family: var(--serif);
  font-weight: 400;
  font-size: 20px;
  line-height: 1.4;
  letter-spacing: -0.005em;
  color: var(--text);
  margin: 0 0 8px;
}
.tl-event .tl-title em {
  font-family: var(--kai);
  font-style: normal;
  color: var(--cyan);
  letter-spacing: 0.04em;
}
.tl-event .tl-desc {
  font-family: var(--sans);
  font-size: 13.5px;
  line-height: 1.7;
  color: var(--text-3);
  margin: 0;
  letter-spacing: 0.01em;
  max-width: 680px;
}
.tl-event .tl-source {
  margin-top: 8px;
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--text-4);
}
.tl-event .tl-source a {
  color: var(--cyan-deep);
  text-decoration: none;
  border-bottom: 1px solid transparent;
}
.tl-event .tl-source a:hover { border-bottom-color: var(--cyan-deep); }

/* responsive */
@media (max-width: 980px) {
  .target-name { font-size: clamp(48px, 12vw, 96px); }
  .target-facts { grid-template-columns: repeat(2, 1fr); }
  .target-fact { border-right: none; }
  .target-fact:nth-child(odd) { border-right: 1px solid var(--border); }
  .target-fact:nth-child(1), .target-fact:nth-child(2) {
    border-bottom: 1px solid var(--border);
  }
  .pipeline-table .pt-row {
    grid-template-columns: 1fr 1fr;
    gap: 16px;
  }
  .pipeline-table .pt-row.pt-head { display: none; }
  .pipeline-table .pt-row .pt-mol { grid-column: 1 / -1; font-size: 16px; }
  .companies-grid { grid-template-columns: repeat(2, 1fr); }
}

@media (max-width: 640px) {
  .target-hero { padding: 64px 0 48px; }
  .target-name {
    font-size: 56px;
    flex-direction: column;
    gap: 6px;
  }
  .target-name .target-cn { font-size: 18px; padding-bottom: 0; }
  .target-summary { font-size: 17px; }
  .target-facts { grid-template-columns: 1fr; }
  .target-fact { border-right: none; border-bottom: 1px solid var(--border); }
  .target-fact:last-child { border-bottom: none; }
  .pipeline-block, .companies-block, .timeline-block { padding: 56px 0; }
  .companies-grid { grid-template-columns: 1fr; }
  .pipeline-table .pt-row {
    grid-template-columns: 1fr;
    padding: 18px 20px;
  }
}